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Association between the prothrombin time-international normalized ratio and concomitant use of antibiotics in warfarin users: Focus on type of antibiotic and its susceptibility to Bacteroides fragilis
http://hdl.handle.net/10271/00003790
http://hdl.handle.net/10271/00003790596c6868-6c18-4609-bf05-e20bcff6d2e1
| 名前 / ファイル | ライセンス | アクション |
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AOP-55-157.pdf (2.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2021-03-18 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Association between the prothrombin time-international normalized ratio and concomitant use of antibiotics in warfarin users: Focus on type of antibiotic and its susceptibility to Bacteroides fragilis | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | warfarin | |||||||||||||||
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| 主題 | antibiotics | |||||||||||||||
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| 主題 | drug interaction | |||||||||||||||
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| 主題 | clinical database system | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Yagi, Tatsuya
× Yagi, Tatsuya
× Naito, Takafumi
× Kato, Ayami
× Hirao, Kensho
× Kawakami, Junichi
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| 書誌情報 |
Annals of Pharmacotherapy 巻 55, 号 2, p. 157-164, 発行日 2021-02-01 |
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| 出版者 | ||||||||||||||||
| 出版者 | SAGE Publications | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | Tatsuya Yagi, Takafumi Naito, Ayami Kato, Kensho Hirao, Junichi Kawakami, Association Between the Prothrombin Time?International Normalized Ratio and Concomitant Use of Antibiotics in Warfarin Users: Focus on Type of Antibiotic and Susceptibility of Bacteroides fragilis to Antibiotics, Annals of Pharmacotherapy, 55(2) pp.157-164. Copyright ?2021 (SAGE Publications). DOI: https://doi.org/10.1177/1060028020940728. | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Background: The difference in type of antibiotics and its susceptibility to Bacteroides fragilis may influence warfarin anticoagulation. However, these influences have not been clarified in clinical settings. Objectives: This study aimed to investigate association between the prothrombin time-international normalized ratio (PT-INR) and concomitant use of antibiotics in real-world population of warfarin users. Methods: This was a single-center cohort study using data from health records and included patients who received β-lactams (BL)/fluoroquinolones (FQ) during ongoing warfarin treatment (2011?2015) at Hamamatsu University Hospital in Japan. Antibiotics were categorized into those which have susceptibility to Bacteroides fragilis (BLsus, FQsus) or non-susceptibility (BLnon, FQnon) and into those given orally (BLpo, FQpo) or intravenously (BLiv, FQiv). Outcomes were excessive PT-INR and changes in PT-INR, defined as the ratio (INR ratio) and difference (ΔINR) of maximum PT-INR and baseline PT-INR. Excessive PT-INR was graded as INR ratio of >1.5 or >2.5. Results: Total of 1,185 warfarin user were included. The proportion of INR ratio >2.5 in FQiv was higher than in BLiv (95% CI: 1.59-46.5). The proportions with an INR ratio of >1.5 in BLsus and FQsus were higher than in BLnon (1.72-14.1) and FQnon (1.05-9.36), respectively. ΔINR values in FQpo, FQiv and FQsus were higher than those in BLpo, BLiv and FQnon, respectively. Conclusions and Relevance: Concomitant use of fluoroquinolones or of antibiotics which are susceptible to Bacteroides fragilis is associated with higher risk of excessive anticoagulation. This findings would contribute to safe and proper antibiotic treatment in warfarin user. |
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| 注記 | ||||||||||||||||
| 内容記述 | 雑誌掲載タイトル: Association Between the Prothrombin Time?International Normalized Ratio and Concomitant Use of Antibiotics in Warfarin Users: Focus on Type of Antibiotic and Susceptibility of Bacteroides fragilis to Antibiotics | |||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 1060-0280 | |||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 1542-6270 | |||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | 32633584 | |||||||||||||||
| 出版社DOI | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1177/1060028020940728 | |||||||||||||||
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| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
