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Development of a novel gripping test for the evaluation of the finger fine motor ability in MPTP-treated monkeys
http://hdl.handle.net/10271/00003851
http://hdl.handle.net/10271/00003851b88c74a8-6a1b-4814-96c5-937edc4c2a88
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (1.1 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2021-05-10 | |||||||
| タイトル | ||||||||
| タイトル | Development of a novel gripping test for the evaluation of the finger fine motor ability in MPTP-treated monkeys | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | Parkinson's disease | |||||||
| キーワード | ||||||||
| 主題 | levodopa | |||||||
| キーワード | ||||||||
| 主題 | deep brain stimulation | |||||||
| キーワード | ||||||||
| 主題 | behavioral test | |||||||
| キーワード | ||||||||
| 主題 | finger fine motor skill | |||||||
| キーワード | ||||||||
| 主題 | gross motor skill | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | MPTP処置をしたサルにおける指微細運動能力評価を目的としたグリッピングテストの新規開発 | |||||||
| 著者 |
小林, 奨
× 小林, 奨
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| 書誌情報 |
en : Journal of Integrative Neuroscience 巻 19, 号 2, p. 209-215, 発行日 2020-06-30 |
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| 出版者 | ||||||||
| 出版者 | IMR Press | |||||||
| 言語 | en | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Assessing the finger fine motor ability is extremely important. However, conventional behavioral tests in monkeys are complicated and costly. We attempted to develop a new task to assess the precise finger grip in Parkinson's disease monkeys based on the principles of objectification, multipurpose, and simplification. This study involved seven adult male cynomolgus monkeys. A gripping test based on the previous food reaching test was developed. Parallel experiments of food reaching test and gripping test affected by the treatments of levodopa and deep brain stimulation of the subthalamic nucleus were performed to verify the utility of the gripping test. We found that gross motor ability (measured by food reaching test) could be significantly improved by both the subthalamic nucleus and levodopa administration, which reproduced the results of our previous study. The finger fine motor ability (measured by the gripping test) could be significantly improved by levodopa administration, but not by the subthalamic nucleus. Our results verified the utility and reliability of the gripping test, which is a simple, convenient, and objective task for evaluating the finger fine motor skill in Parkinson's disease monkeys. Mechanisms of the efficacy of deep brain stimulation on fine motor ability require further investigation. | |||||||
| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2020-09-18 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第843号 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 0219-6352 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1757-448X | |||||||
| PubMed番号 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 32706185 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.31083/j.jin.2020.02.158 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
