| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-05-29 |
| タイトル |
|
|
タイトル |
Effect of Ulcerative Colitis Duration on the Usefulness of Immunochemical Fecal Occult Blood Test Result as a Disease Activity Biomarker |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
ulcerative colitis |
| キーワード |
|
|
主題 |
disease duration |
| キーワード |
|
|
主題 |
fecal immunochemical test |
| キーワード |
|
|
主題 |
prostaglandin E-major urinary metabolite |
| キーワード |
|
|
主題 |
C-reactive protein |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
Effect of UC Duration on FIT |
| 著者 |
Ishida, Natsuki
Miyazu, Takahiro
Matsuura, Tomoharu
Takano, Ryosuke
Tamura, Satoshi
Kagami, Takuma
Tani, Shinya
Yamade, Mihoko
Hamaya, Yasushi
Iwaizumi, Moriya
Osawa, Satoshi
Furuta, Takahisa
Sugimoto, Ken
|
| 書誌情報 |
International Journal of Colorectal Disease
巻 35,
号 9,
p. 1729-1739,
発行日 2020-09
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利 |
|
|
権利情報 |
"This is a post-peer-review, pre-copyedit version of an article published in ""International Journal of Colorectal Disease"". The final authenticated version is available online at: https://doi.org/10.1007/s00384-020-03636-5." |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: The effects of ulcerative colitis (UC) duration on biomarker accuracy are unknown. We investigated the effects of UC duration on the predictive accuracy of biomarkers including immunochemical fecal occult blood test (FOBT, also known as FIT), prostaglandin E-major urinary metabolite (PGE-MUM), and C-reactive protein (CRP).
Methods: We divided 133 samples into groups based on disease duration. Clinical and endoscopic remission was defined as Lichtiger’s clinical activity index (CAI) of ?4, Mayo endoscopic subscore (MES) of 0, and UC endoscopic index of severity (UCEIS) of ?1.
Results: FIT results were significantly correlated with all activity scores when the disease duration was <4 years. When the disease duration was ?4 years, FIT results were significantly correlated with the CAI and MES but not with UCEIS. When the disease duration was ?5 years, FIT and CAI were significantly correlated, whereas FIT and MES or FIT and UCEIS did not show any correlation. When the duration was ?4 years, PGE-MUM and CRP showed a significant correlation with CAI, MES, and UCEIS. Receiver operating characteristic curve analysis of biomarker data for predicting endoscopic remission showed that the accuracy of FIT was superior to that of PGE-MUM and CRP in the <4 year group.
Conclusions: FIT is an accurate biomarker reflecting the endoscopic score until 4 years in patients with UC. However, owing to the increased number of false negatives, the usefulness of FIT may decline after 4 years. Hence, evaluation of UC in combination with other biomarkers is recommended. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0179-1958 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1432-1262 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
32472230 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00384-020-03636-5 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
IJCD-35-1729.pdf (1.5 MB)
