Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain

衞藤, 史博

doi:https://doi.org/10.1038/s41598-020-64277-w

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Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain

http://hdl.handle.net/10271/00003874

名前 / ファイル	ライセンス	アクション
論文本文 (5.2 MB)

Item type

学位論文 / Thesis or Dissertation(1)

公開日

2021-08-01

タイトル

Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain

言語

eng

資源タイプ

資源タイプ識別子

http://purl.org/coar/resource_type/c_db06

資源タイプ

doctoral thesis

アクセス権

open access

アクセス権URI

http://purl.org/coar/access_right/c_abf2

その他のタイトル

マウス脳におけるグルタミン酸及びγ-アミノ酪酸量に対するScrapperの領域特異的な効果

著者

衞藤, 史博

書誌情報

en : Scientific Reports

巻 10, p. 7435, 発行日 2020-05-04

出版者

Springer Nature

言語

権利

言語

権利情報

Copyright The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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内容記述タイプ

Abstract

内容記述

The brain consists of various areas with anatomical features. Neurons communicate with one another via excitatory or inhibitory synaptic transmission. Altered abundance of neurotransmitters, including glutamate and gamma-aminobutyric acid (GABA), in specific brain regions is closely involved in severe neurological diseases, such as schizophrenia and obsessive-compulsive disorder. SCRAPPER, a ubiquitin E3 ligase, regulates synaptic transmission. Scrapper gene deficiency results in defective neurotransmission due to excessive secretion of neurotransmitters. The present study employed matrix-assisted laser desorption/ionization imaging mass spectrometry to analyze the abundance of amino acid neurotransmitters in Scrapper knockout (SCR-KO) mice. SCR-KO mice exhibited significantly increased glutamate levels in the isocortex (CTX), corpus callosum (CC), thalamus (TH), midbrain (MB), cerebellar cortex (CBX), and caudoputamen (CP) and increased GABA levels in the CTX, CC, TH, MB, CBX and hypothalamus (HY) compared with wild-type mice. These findings indicate that Scrapper deficiency leads to upregulated glutamate and GABA levels in multiple regions. Our results show a differential, region-specific effect of Scrapper on the abundance of glutamate and GABA.

言語

学位名

博士（医学）

学位の区分

内容記述

doctoral

学位の分野

内容記述

医学系研究科

学位授与機関

学位授与機関識別子Scheme

kakenhi

学位授与機関識別子

13802

学位授与機関名

浜松医科大学

学位授与年月日

2021-03-16

学位授与番号

甲第866号

ISSN

収録物識別子タイプ

PISSN

収録物識別子

2045-2322

PubMed番号

識別子タイプ

PMID

Versions

Ver.1

2023-06-20 16:26:06.290572

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Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain

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