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  1. 学位論文
  2. 博士論文（医学）
  3. 本文

Daikenchuto increases blood flow in the superior mesenteric artery in humans: A comparison study between four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction magnetic resonance imaging and Doppler ultrasound

http://hdl.handle.net/10271/00003876
http://hdl.handle.net/10271/00003876
c14c3f97-248d-40b2-abc5-b3186eda9513
名前 / ファイル ライセンス アクション
DT_871ronbun.pdf 論文本文 (1.1 MB)
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Item type 学位論文 / Thesis or Dissertation(1)
公開日 2021-08-01
タイトル
タイトル Daikenchuto increases blood flow in the superior mesenteric artery in humans: A comparison study between four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction magnetic resonance imaging and Doppler ultrasound
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_db06
資源タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
その他のタイトル
その他のタイトル 大建中湯はヒト上腸間膜動脈の血流を増加させる: 4D PC-VIPRと超音波の比較検討試験
著者 鈴木, 克徳

× 鈴木, 克徳

ja 鈴木, 克徳
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書誌情報 en : PLOS ONE

巻 16, 号 1, p. e0245878, 発行日 2021-01-27
出版者
出版者 Public Library of Science (PLoS)
言語 en
権利
言語 en
権利情報 Copyright 2021 Suzuki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
抄録
内容記述タイプ Abstract
内容記述 Respiratory-gated four-dimensional phase-contrast vastly undersampled isotropic projection reconstruction (4D PC-VIPR) is magnetic resonance (MR) imaging technique that enables analysis of vascular morphology and hemodynamics in a single examination using cardiac phase resolved 3D phase-contrast magnetic resonance imaging. The present study aimed to assess the usefulness of 4D PC-VIPR for the superior mesenteric artery (SMA) flowmetry before and after flow increase was induced by the herbal medicine Daikenchuto (TJ-100) by comparing it with Doppler ultrasound (DUS) as a current standard. Twenty healthy volunteers were enrolled in this prospective single-arm study. The peak cross-sectionally averaged velocity was measured by 4D PC-VIPR, peak velocity was measured by DUS, and flow volume (FV) of SMA and aorta were measured by 4D PC-VIPR and DUS 25 min before and after the peroral administration of TJ-100. The peak cross-sectionally averaged velocity, peak velocity, and FV of SMA measured by 4D PC-VIPR and DUS significantly increased after administration of TJ-100 (4D PC-VIPR: the peak cross-sectionally averaged velocity; p=0.004, FV; p=0.035, DUS: the peak velocity; p=0.003, FV; p=0.010). Furthermore, 4D PC-VIPR can analyze multiple blood vessels simultaneously. The ratio of the SMA FV to the aorta, before and after oral administration on the 4D PC-VIPR test also increased (p=0.015). The rate of change assessed by 4D PC-VIPR and DUS were significantly correlated (the peak cross-sectionally averaged velocity and peak velocity: r=0.650; p=0.005, FV: r=0.659; p=0.004). Retrospective 4D PC-VIPR was a useful modality for morphological and hemodynamic analysis of SMA.
言語 en
学位名
学位名 博士（医学）
学位の区分
内容記述 doctoral
学位の分野
内容記述 医学系研究科
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13802
学位授与機関名 浜松医科大学
学位授与年月日
学位授与年月日 2021-03-16
学位授与番号
学位授与番号 甲第871号
EISSN
収録物識別子タイプ EISSN
収録物識別子 1932-6203
PubMed番号
識別子タイプ PMID
関連識別子 33503053
出版社DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1371/journal.pone.0245878
著者版フラグ
出版タイプ VoR
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