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  1. 学術雑誌論文
  2. 各雑誌掲載論文

New strategy for MS treatment with autoantigen-modified liposomes and their therapeutic effect

http://hdl.handle.net/10271/00003897
http://hdl.handle.net/10271/00003897
21a89367-c534-4099-9a12-974df172a5be
名前 / ファイル ライセンス アクション
JCR-335-389.pdf JCR-335-389.pdf (8.1 MB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-10-05
タイトル
タイトル New strategy for MS treatment with autoantigen-modified liposomes and their therapeutic effect
言語 en
言語
言語 eng
キーワード
主題 Autoantigen-modified liposome
キーワード
主題 Autoantigen-recognizing T cell
キーワード
主題 Experimental autoimmune encephalomyelitis
キーワード
主題 Multiple sclerosis
キーワード
主題 Spleen
キーワード
主題 Targeting
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Shimizu, Kosuke

× Shimizu, Kosuke

en Shimizu, Kosuke

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Agata, Kazuki

× Agata, Kazuki

en Agata, Kazuki

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Takasugi, Shohei

× Takasugi, Shohei

en Takasugi, Shohei

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Goto, Shungo

× Goto, Shungo

en Goto, Shungo

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Narita, Yudai

× Narita, Yudai

en Narita, Yudai

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Asai, Tomohiro

× Asai, Tomohiro

en Asai, Tomohiro

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Magata, Yasuhiro

× Magata, Yasuhiro

en Magata, Yasuhiro

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Oku, Naoto

× Oku, Naoto

en Oku, Naoto

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書誌情報 en : Journal of Controlled Release

巻 335, p. 389-397, 発行日 2021-07-10
出版者
出版者 Elsevier
言語 en
権利
権利情報 Copyright 2021 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
権利
権利情報 This is the Published journal article version. The formal published version is available at "https://doi.org/10.1016/j.jconrel.2021.05.027".
抄録
内容記述タイプ Abstract
内容記述 As current treatments for multiple sclerosis (MS) remain chemotherapeutic ones directed toward symptoms, the development of a curative treatment is urgently required. Herein, we show an autoreactive immune celltargetable approach using autoantigen-modified liposomes for the curative treatment of MS. In these experiments, experimental autoimmune encephalomyelitis (EAE) induced by autoantigenic myelin oligodendrocyte glycoprotein (MOG) peptide was used as a model of primary progressive MS, and MOG-modified liposomes encapsulating doxorubicin (MOG-LipDOX) were used as a therapeutic drug. The results showed that the progression of encephalomyelitis symptoms was significantly suppressed by MOG-LipDOX injection, whereas the other samples failed to show any effect. Additionally, invasion of inflammatory immune cells into the spinal cord and demyelination of neurons were clearly suppressed in the MOG-LipDOX-treated mice. FACS analysis revealed that the number of both MOG-recognizable CD4+ T cells in the spleen was obviously decreased after MOGLipDOX treatment. Furthermore, the number of effector Th17 cells in the spleen was significantly decreased and that of regulatory Treg cells was concomitantly increased. Finally, we demonstrated that myelin proteolipid protein (PLP)-modified liposomes encapsulating DOX (PLP-LipDOX) also showed the therapeutic effect on relapsing-remitting EAE. These findings indicate that autoantigen-modified liposomal drug produced a highly therapeutic effect on EAE by delivering the encapsulated drug to autoantigen-recognizable CD4+ T cells and thus suppressing autoreactive immune responses. The present study suggests that the use of these autoantigenmodified liposomes promises to be a suitable therapeutic approach for the cure of MS.
注記
内容記述 <参照>出版社サイト:https://doi.org/10.1016/j.jconrel.2021.05.027
ISSN
収録物識別子タイプ PISSN
収録物識別子 0168-3659
EISSN
収録物識別子タイプ EISSN
収録物識別子 1873-4995
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 34033858
出版社DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1016/j.jconrel.2021.05.027
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
出版社版
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.jconrel.2021.05.027
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