| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-10-14 |
| タイトル |
|
|
タイトル |
Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: a multi-institutional randomized controlled trial |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Polaprezinc |
| キーワード |
|
|
主題 |
Oral mucositis |
| キーワード |
|
|
主題 |
Chemotherapy |
| キーワード |
|
|
主題 |
Hematopoietic stem cell transplantation |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
Polaprezinc for prevention of oral mucositis |
| 著者 |
Kitagawa, Junichi
Kobayashi, Ryo
Nagata, Yasuyuki
Kasahara, Senji
Ono, Takaaki
Sawada, Michio
Ohata, Koichi
Kato-Hayashi, Hiroko
Hayashi, Hideki
Shimizu, Masahito
Itoh, Yoshinori
Tsurumi, Hisashi
Suzuki, Akio
|
| 書誌情報 |
International Journal of Cancer
巻 148,
号 6,
p. 1462-1469,
発行日 2021-03-15
|
| 出版者 |
|
|
出版者 |
John Wiley and Sons |
| 権利 |
|
|
権利情報 |
"This is the peer reviewed version of the following article: ""Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: a multi-institutional randomized controlled trial"", International Journal of Cancer; 148(6): p1462-1469, 2021, which has been published in final form at https://doi.org/10.1002/ijc.33316. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited." |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Oral mucositis is a common and distressing complication in patients receiving high-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single-center retrospective analysis that zinc-L-carnosine (polaprezinc, PZ) reduced the incidence of oral mucositis associated with HSCT. To verify the accuracy of the prophylactic effect of PZ against oral mucositis, we carried out a multi-institutional prospective randomized controlled study. Patients were randomly allocated to either the prevention group, in which PZ lozenge treatment was started before chemotherapy, or the control group, in which administration of PZ lozenges was initiated immediately after the onset of Grade 2 oral mucositis. Oral mucositis was evaluated daily from the start of chemotherapy to 35 days after transplantation. A total of 91 patients were enrolled, and 88 patients (47 in the control group and 41 in the prevention group) were eligible for data analysis. The incidence of Grade ? 2 but not Grade ? 3 oral mucositis was significantly reduced in the prevention group compared to the control group (44.7% in control group vs 22.0% in the prevention group, P=0.025). There were no significant differences in the incidence rates of other adverse events or the rate of engraftment (95.6% vs 97.2%, P=0.693) between the two groups. These findings suggest that PZ lozenge is effective for prophylaxis against Grade ? 2 oral mucositis associated with chemotherapy in patients undergoing HSCT without any influence on the HSCT outcome. |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0020-7136 |
| EISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1097-0215 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
32984946 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1002/ijc.33316 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
IJC-148-1462.pdf (942.9 kB)
