| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-11-16 |
| タイトル |
|
|
タイトル |
Hemodynamic changes in neonates born to mothers with Graves' disease |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Neonatal hyperthyroidism |
| キーワード |
|
|
主題 |
Cardiac Output |
| キーワード |
|
|
主題 |
N-terminal-pro-B-type natriuretic peptide |
| キーワード |
|
|
主題 |
Thyroid-stimulating hormone receptor antibody |
| キーワード |
|
|
主題 |
Echocardiography |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
Hemodynamics in newborns and Graves’ disease |
| 著者 |
Ishikawa, Takamichi
Uchiyama, Hiroki
Iwashima, Satoru
Baba, Toru
Ohishi, Akira
Iijima, Shigeo
Itoh, Hiroaki
|
| 書誌情報 |
Endocrine
巻 72,
号 1,
p. 171-178,
発行日 2021-04
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利 |
|
|
権利情報 |
This is a post-peer-review, pre-copyedit version of an article published in "Endocrine". The final authenticated version is available online at: https://doi.org/10.1007/s12020-020-02443-w. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Cardiac insufficiency is a major morbidity in neonatal hyperthyroidism. It is important to assess the hemodynamics in neonates born to mothers with Graves’ disease (GD). This study prospectively evaluated the hemodynamic changes in neonates born to mothers with GD.
Methods: Overall, 80 newborns were enrolled. Thirty-six neonates were born to mothers with GD who were positive for thyroid-stimulating hormone (TSH) receptor antibody (TRAb), and 44 were born to mother negative for TRAb. The serum levels of TSH, free triiodothyronine (FT3), free thyroxine (FT4), and N-terminal-pro-B-type natriuretic peptide (NT-proBNP), the cardiac output, and cardiac index (CI) evaluated by echocardiography were compared between the two groups at several postnatal points (day of delivery and 5, 10, and 30 days of life).
Results: The TRAb-positive newborns had higher FT4 levels and CI on Day 5 (both p<0.05) and higher FT3 (p<0.05) and FT4 levels (p<0.01) and CI (p<0.01) but lower TSH levels (p<0.05) on Day 10 than the TRAb-negative newborns. The TRAb-positive newborns had significantly higher NT-proBNP levels on Days 5 (median 752 vs. 563 pg/mL, p=0.034) and 10 (median 789 vs. 552 pg/mL, p=0.002) than the TRAb-negative newborns.
Conclusions: Hemodynamic changes in 1 neonates born to TRAb-positive mothers with GD resulted in a higher CI and NT-proBNP levels than in those with TRAb-negative mothers from postnatal days 5 to 10. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1355-008X |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1559-0100 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
32785898 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s12020-020-02443-w |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Endocrine-72-171.pdf (952.3 kB)
