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  1. 学術雑誌論文
  2. 各雑誌掲載論文

Clinical outcome of condoliase injection treatment for lumbar disc herniation: Indications for condoliase therapy

http://hdl.handle.net/10271/00003945
http://hdl.handle.net/10271/00003945
851d9f5f-ec11-4a83-9724-cdd40fc81217
名前 / ファイル ライセンス アクション
J J Orthop Sci-26-79.pdf (1.2 MB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2022-02-01
タイトル
タイトル Clinical outcome of condoliase injection treatment for lumbar disc herniation: Indications for condoliase therapy
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Banno, Tomohiro

× Banno, Tomohiro

Banno, Tomohiro

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Hasegawa, Tomohiko

× Hasegawa, Tomohiko

Hasegawa, Tomohiko

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Yamato, Yu

× Yamato, Yu

Yamato, Yu

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Yoshida, Go

× Yoshida, Go

Yoshida, Go

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Yasuda, Tatsuya

× Yasuda, Tatsuya

Yasuda, Tatsuya

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Arima, Hideyuki

× Arima, Hideyuki

Arima, Hideyuki

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Oe, Shin

× Oe, Shin

Oe, Shin

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Ushirozako, Hiroki

× Ushirozako, Hiroki

Ushirozako, Hiroki

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Yamada, Tomohiro

× Yamada, Tomohiro

Yamada, Tomohiro

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Ide, Koichiro

× Ide, Koichiro

Ide, Koichiro

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Watanabe, Yu

× Watanabe, Yu

Watanabe, Yu

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Matsuyama, Yukihiro

× Matsuyama, Yukihiro

Matsuyama, Yukihiro

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書誌情報 Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association

巻 26, 号 1, p. 79-85, 発行日 2021-01
出版者
出版者 Elsevier
権利
権利情報 © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
権利
権利情報 This is the accepted manuscript version. The formal published version is available at "https://doi.org/10.1016/j.jos.2020.02.002".
権利
権利情報 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.
抄録
内容記述タイプ Abstract
内容記述 Background
Condoliase is a novel, potent chemonucleolytic drug available for clinical use for lumbar disc herniation (LDH) in Japan. The aim of this study was to assess the clinical outcome of condoliase therapy in patients with LDH, as well as factors affecting the clinical outcome.
Methods
We enrolled patients with LDH who were receiving condoliase injection. The following baseline data were collected: symptom duration; herniation level and type; T2 signal intensity of herniation; adverse events; rates of spondylolisthesis, posterior intervertebral angle of ≥5°, and vertebral body translation of ≥3 mm. Change in disc height, disc degeneration, herniation size, visual analogue scale (VAS) for leg and back pain, and Oswestry Disability Index (ODI) were evaluated at the baseline, and 3-month follow-up. These data were compared between patients with efficacious (VAS improvement of ≥20 mm; group E) and inefficacious (VAS improvement <20 mm or required operation; group I) for condoliase treatment.
Results
Forty-seven patients (20 women, 27 men; mean age 48 years) were included. The herniation level was L2/3 in one patient, L3/4 in two, L4/5 in 23, and L5/S1 in 21. Median symptom duration was 8 months. The mean VAS and ODI improved significantly from the baseline to 3-month follow-up (p<0.01). Group E included 33 patients (70.2%) and group I included 14, three of whom had a history of discectomy. The rates of spondylolisthesis and posterior intervertebral angle ≥5° were significantly higher in group I than in group E. However, the rates of trans-ligamentous type and herniation with high signal intensity on T2-weighted images (highT2) were significantly higher in group E. Reduction of disc herniation was more frequently observed in group E.
Conclusions
Condoliase injection resulted in significantly improved symptoms in patients with LDH. Condoliase therapy was less effective for patients with a history of discectomy, spondylolisthesis, or those with a posterior intervertebral angle ≥5°, while trans-ligamentous type and high T2 herniation were associated with increased efficacy.
ISSN
収録物識別子タイプ ISSN
収録物識別子 0949-2658
EISSN
収録物識別子タイプ ISSN
収録物識別子 1436-2023
PubMed番号
関連タイプ isVersionOf
識別子タイプ PMID
関連識別子 32111547
医中誌論文ID
関連タイプ isVersionOf
識別子タイプ ICHUSHI
関連識別子 2022017959
出版社DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1016/j.jos.2020.02.002
著者版フラグ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
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