| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Congenital Infection and Disorders of Brain Development : With Special Reference to Congenital Cytomegalovirus Infection |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
congenital infection |
| キーワード |
|
|
主題 |
cytomegalovirus |
| キーワード |
|
|
主題 |
brain development |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| その他のタイトル |
|
|
その他のタイトル |
【Review】 |
| 著者 |
筒井, 祥博
小杉, 伊三夫
新村, 祐一郎
長浜, 真人
|
| 書誌情報 |
en : Congenital anomalies
巻 37,
号 1,
p. 1-14,
発行日 1997-03-31
|
| 出版者 |
|
|
出版者 |
日本先天異常学会 |
|
言語 |
ja |
| 出版者 |
|
|
出版者 |
John Wiley and Sons |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
(C) 日本先天異常学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Intrauterine infections of various microorganisms have the potential to induce brain abnormalities in the fetus and newborn infant. Among the infectious pathogens, cytomegalovirus (CMV) is the most significant infectious cause of brain abnormalities, with variations from fatal cytomegalic inclusion disease to functional brain disorders, such as mental retardation or epilepsy. Here, we present three autopsy cases of congenital CMV infection, and we review the features of the brain abnormalities of congenital CMV infection. A ventriculofugal spread of infection seems to be characteristics of congenital CMV-infected brains and is suggested to be the cause of neuronal migration disorders, resulting in brain malformations, such as microcephaly, lissencephaly and polymicrogyria. We also present an experimental animal model for congenital CMV infection. With the model we showed that murine cytomegalovirus (MCMV) infection in the developing mouse brain caused a disturbance of neuronal migration and neuronal cell loss, detected with morphometric measurements by labeling the neuronal precursor cells with BrdU. As shown by immunohistochemical double staining of BrdU and viral-antigen, infected neuronal cells constituted only a part of the disordered neuronal cells, suggesting that an indirect effect of vital infection on neuronal cells also contributes the migration disorders presumably mediated by cytokines or the induction of apoptosis. Neuronal migration disorders caused by MCMV infection are also discussed with reference to those caused by X-irradiation. |
| ISSN |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0914-3505 |
| EISSN |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1741-4520 |
| NII論文ID |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
NAID |
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|
関連識別子 |
110002787970 |
| NII書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN10066760 |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/j.1741-4520.1997.tb00543.x |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
110002787970.pdf (1.8 MB)
