| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-03-01 |
| タイトル |
|
|
タイトル |
Subcutaneous injection of interferon gamma therapy could be useful for anti–IFN-γ autoantibody associated disseminated nontuberculous mycobacterial infection |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
disseminated nontuberculous mycobacterial infection |
| キーワード |
|
|
主題 |
anti–IFN-γ autoantibody |
| キーワード |
|
|
主題 |
interferon gamma therapy |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Harada, Masanori
Furuhashi, Kazuki
Karayama, Masato
Suzuki, Yuzo
Hozumi, Hironao
Enomoto, Noriyuki
Fujisawa, Tomoyuki
Nakamura, Yutaro
Inui, Naoki
Suda, Takafumi
|
| 書誌情報 |
Journal of Infection and Chemotherapy
巻 27,
号 2,
p. 373-378,
発行日 2021-02
|
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利 |
|
|
権利情報 |
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利 |
|
|
権利情報 |
This is the accepted manuscript version. The formal published version is available at "https://doi.org/10.1016/j.jiac.2020.09.031". |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
One of the human natural defense systems protects against nontuberculous mycobacterial (NTM) infection by IFN-γ producing T lymphocyte cells. Most disseminated NTM infections usually occur in severe immune-compromised patients, such as HIV infection or after organ transplant patients. However, there have been several reports of non-compromised patients with disseminated NTM infection, including antibiotic resistance cases and the presence of a neutralizing antibody against IFN-γ. We elucidated the anti-IFN-γ neutralizing antibody in a 65 year-old Japanese man whose legs were paralyzed because of multiple abscesses in vertebral bodies. Although his vertebral bodies were released due to an operation and antibiotics were administered, this treatment efficacy was poor. Patient’s plasma demanded not only IFN-γ expression in peripheral blood mononuclear cells (PBMC) obtained from healthy controls, but also recombinant human IFN-γ expression. Furthermore, IFN-γ receptor expression was increased, compared to the healthy control. Finally, anti-IFN-γ antibody was detected in his plasma. These results suggested that anti-IFN-γ antibody induced an incurable NTM infection. IFN-γ was subcutaneously administrated with antibiotics, and then the abscesses diminished and his general condition was successfully improved. This therapy might be useful against severe NTM infections. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1341-321X |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1437-7780 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
33071037 |
| 医中誌論文ID |
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|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
ICHUSHI |
|
|
関連識別子 |
2021313263 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jiac.2020.09.031 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
JIC-27-373.pdf (1.0 MB)
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