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Evaluation of aging, diabetes mellitus, and skin wounds by scanning acoustic microscopy with protease digestion
http://hdl.handle.net/10271/00004083
http://hdl.handle.net/10271/00004083e07271df-c0dc-4815-9e24-bece2fdd1b60
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PBA-8-1516072.pdf (3.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2022-03-16 | |||||||||
| タイトル | ||||||||||
| タイトル | Evaluation of aging, diabetes mellitus, and skin wounds by scanning acoustic microscopy with protease digestion | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | Scanning acoustic microscopy | |||||||||
| キーワード | ||||||||||
| 主題 | skin | |||||||||
| キーワード | ||||||||||
| 主題 | aging | |||||||||
| キーワード | ||||||||||
| 主題 | diabetes mellitus | |||||||||
| キーワード | ||||||||||
| 主題 | wound | |||||||||
| キーワード | ||||||||||
| 主題 | elasticity | |||||||||
| キーワード | ||||||||||
| 主題 | protease | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Miura, Katsutoshi
× Miura, Katsutoshi
× Yamashita, Kanna
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| 書誌情報 |
Pathobiology of Aging and Age-related Diseases 巻 8, 号 1, p. 1516072, 発行日 2018-09-06 |
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| 出版者 | ||||||||||
| 出版者 | Taylor & Francis | |||||||||
| 権利 | ||||||||||
| 権利情報 | © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. | |||||||||
| 権利 | ||||||||||
| 権利情報 | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Scanning acoustic microscopy (SAM) can assess tissue stiffness by calculating the speed of sound (SOS) through tissues. SOS increases as tissue stiffness increases. Sensitivity to protease digestion depends on protein type, concentration, and modification. We analyzed the SOS images of formalin-fixed paraffin-embedded skin sections from elderly, young, diabetic, and nondiabetic subjects, as well as chronic and acute wounds. SAM provided high-resolution histology similar to LM and revealed characteristic SOS alteration following pepsin treatment. SOS values of dermis samples from elderly subjects (especially females) were lower than those of younger adults, which was indicative of age-related dermal softening and loosening. SOS values of elderly females were lower than those of younger females and elderly males. Dermal SOS showed a positive correlation with epidermal thickness. SOS values of epidermis of elderly subjects were higher than those of younger adults and showed a rapid decline 0.5h after protease digestion. Reticular dermis of diabetic patients exhibited greater pepsin resistance than that of nondiabetic patients. Chronic wounds exhibited greater SOS values and pepsin resistance than acute wounds. SOS variation with aging, diabetes mellitus, and wound fibrosis reflected histological and mechanical changes associated with senescence and disease duration. Epidermal thickness reflects age-related changes in dermal stiffness. | |||||||||
| EISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 2001-0001 | |||||||||
| PubMed番号 | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 30220987 | |||||||||
| 出版社DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1080/20010001.2018.1516072 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
