| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-04-08 |
| タイトル |
|
|
タイトル |
難治性喉頭乳頭腫7例の検討 |
| タイトル |
|
|
タイトル |
A Study on Seven Cases of Intractable Laryngeal Papillomatosis |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
主題 |
laryngeal papillomatosis |
| キーワード |
|
|
主題 |
Human papillomavirus (HPV) |
| キーワード |
|
|
主題 |
surgery |
| キーワード |
|
|
主題 |
adjuvant therapy |
| キーワード |
|
|
主題 |
p16 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
山田, 智史
今井, 篤志
三澤, 清
望月, 大極
山口, 裕貴
岡村, 純
大久保, 亜季
杉山, 健一
高橋, 吾郎
瀧澤, 義徳
細川, 誠二
峯田, 周幸
|
| 書誌情報 |
耳鼻咽喉科臨床 補冊 = Practica oto-rhino-laryngologica. Suppl.
巻 156,
p. 8-15,
発行日 2021-02-01
|
| 出版者 |
|
|
出版者 |
耳鼻咽喉科臨床学会 |
| 出版者 |
|
|
出版者 |
The Society of Practical Otolaryngology |
| 権利 |
|
|
権利情報 |
出版者の許諾を得て掲載 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Laryngeal papillomatosis is caused by infection with human papillomavirus (HPV) type 6 and/or 11. Laryngeal papillomatosis recurs frequently, and malignant transformation occurs in 1.6%-4% of the cases. Surgery is the treatment of first choice. While adjuvant therapies such as interferon, Chinese medicines, proton pump inhibitors, indole 3 carbinol, cidofovir and vaccines have been tried, none has come to be positioned as the standard of care.
We report seven patients with laryngeal papillomatosis who underwent multiple surgeries. All were men. The surgery was performed in combination with two or three of the following: use of an electric scalpel, CO2 laser, YAG laser, sharp resection, and intralesional injection of cidofovir. Intralesional injection of cidofovir after resection was performed in four cases, and remission was achieved in three of these cases. Cidofovir is an unapproved drug in Japan and is not yet approved for use in cases of laryngeal papillomatosis in other countries. However, the outcomes in our cases and other reports suggest that intralesional injection of cidofovir is effective.
HPV6 (n=5), HPV11 (n=1) and HPV negative (n=1) detected respectively. Malignant transformation occurred in one case and HPV negative. Moreover, p16 immunohistochemistry was performed in all cases. However, no relation with number of operations and HPV status was found.
The life cycle of HPV in laryngeal papillomatosis is largely unknown, and there is no consensus on methods of treatment other than surgery. More research is needed to elucidate the life cycle of HPV and the pathophysiology of laryngeal papillomatosis. |
| 注記 |
|
|
内容記述 |
浜松医科大学医学部耳鼻咽喉科・頭頸部外科学教室 峯田周幸教授退任記念論文集～症例から学ぶ～ |
| 注記 |
|
|
内容記述 |
Festschrift for Professor Hiroyuki Mineta In Hornor of His Retirement as Chairman of Hamamatsu University School of Medicine |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0912-1870 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2185-1557 |
| 医中誌論文ID |
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|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
ICHUSHI |
|
|
関連識別子 |
2021267583 |
| 出版社DOI |
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|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.5631/jibirinsuppl.156.8 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
耳鼻臨床補冊-156-8.pdf (1.5 MB)
