| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-05-06 |
| タイトル |
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|
タイトル |
Effects of pirenzepine on vonoprazan-induced gastric acid inhibition and hypergastrinemia |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
potassium-competitive acid blocker |
| キーワード |
|
|
主題 |
vonoprazan |
| キーワード |
|
|
主題 |
pirenzepine |
| キーワード |
|
|
主題 |
M1 muscarinic receptor antagonist |
| キーワード |
|
|
主題 |
intragastric pH |
| キーワード |
|
|
主題 |
gastrin |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
Vonoprazan and Pirenzepine |
| 著者 |
Suzuki, Takahiro
Higuchi, Tomohiro
Kagami, Takuma
Uotani, Takahiro
Yamade, Mihoko
Tani, Shinya
Hamaya, Yasushi
Iwaizumi, Moriya
Osawa, Satoshi
Sugimoto, Ken
Miyajima, Hiroaki
Furuta, Takahisa
|
| 書誌情報 |
European Journal of Clinical Pharmacology
巻 77,
号 7,
p. 971-978,
発行日 2021-07
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利 |
|
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00228-021-03162-5 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Backgrounds: Compared to proton pump inhibitors, vonoprazan exerts a greater inhibitory effect on gastric acid secretion and is useful for treating acid-related diseases, such as gastro-esophageal reflux disease. However, there is a problem that vonoprazan causes hypergastrinemia, which confers a risk of carcinoid tumor. A previous report demonstrated that pirenzepine, an M1 muscarinic receptor antagonist, enhances the acid inhibitory effects while suppressing hypergastrinemia induced by omeprazole. Here, we examined whether pirenzepine enhances the gastric acid inhibitory effects of vonoprazan without further increasing serum gastrin levels.
Methods: Eleven healthy volunteers were subjected to 24-hour intragastric pH monitoring and serum gastrin measurements on day 7 of three different regimens: pirenzepine 75mg alone, vonoprazan 10mg alone, and vonoprazan 10mg plus pirenzepine 75mg administered in a randomized crossover fashion.
Results: Median pH 4 holding time ratios (range) achieved with pirenzepine 75mg, vonoprazan 10mg and vonoprazan 10mg plus pirenzepine 75mg were 6.9% (2.4?32.8%), 88.4% (54.6?100%), and 84.2% (40.3?100%), respectively. Respective serum gastrin levels were 79 (75?210) pg/ml, 310 (110?870) pg/ml, and 170 (140?930) pg/ml. In cases with hypergastrinemia (gastrin?200pg/ml) induced by vonoprazan 10mg alone, concomitant treatment with pirenzepine significantly reduced serum gastrin levels from 370pg/ml to 180pg/ml (P=0.028).
Conclusion: Although pirenzepine does not enhance acid inhibition, it does improve hypergastrinemia induced by vonoprazan to some extent. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0031-6970 |
| EISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1432-1041 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
34059932 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00228-021-03162-5 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
EJCP-77-971.pdf (1.0 MB)
