| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-07-06 |
| タイトル |
|
|
タイトル |
Inhibitory Effects of Amniotic Fluid on the Activated Protein C Anticoagulation System in Maternal Plasma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Activated protein C |
| キーワード |
|
|
主題 |
Amniotic fluid |
| キーワード |
|
|
主題 |
Coagulation |
| キーワード |
|
|
主題 |
Endogenous thrombin potential |
| キーワード |
|
|
主題 |
Pregnancy |
| キーワード |
|
|
主題 |
Pulmonary thromboembolism |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Jain, Divyanu
Oda, Tomoaki
Kawai, Kenta
Horikoshi, Yoshimasa
Matsumoto, Masako
Narumi, Megumi
Kohmura-Kobayashi, Yukiko
Furuta-Isomura, Naomi
Yaguchi, Chizuko
Uchida, Toshiyuki
Suzuki, Kazunao
Kanayama, Naohiro
Itoh, Hiroaki
Tamura, Naoaki
|
| 書誌情報 |
Journal of Thrombosis and Thrombolysis
巻 53,
号 1,
p. 208-212,
発行日 2022-01
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利 |
|
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11239-021-02513-4 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Pulmonary thromboembolism (PTE) is one of the leading causes of maternal mortality. We previously reported that possible contamination of amniotic fluid (AF) into maternal circulation accelerated thrombin production and activated platelet function in maternal blood through the extrinsic pathway, which may be associated with the high incidence of PTE in early puerperium. However, it remains unclear whether the maternal anticoagulation system, e.g., the activated protein C (APC) pathway, contributes to the hypercoagulable condition induced by AF. Our previous study using an endogenous thrombin potential (ETP)-based assay revealed that sensitivity to APC was reduced during the postpartum first day, i.e., immediately after delivery, when parturients were supposed to be exposed to AF. Our aim is to investigate the susceptibility of maternal plasma to APC when mixed with AF. We collected plasma from 51 pregnant females and mixed with AF as well as APC. APC-sensitivity ratio (APC-sr) was calculated using the ETP-based assay. Addition of AF to maternal plasma showed a significant increase of ETP in the presence of APC. APC-sr was significantly increased, indicating decreased sensitivity to APC, after AF mixture to maternal plasma. The present APC-sr difference with AF contamination was smaller than that we reported previously in venous thromboembolism cases. The inhibitory effects of AF on the APC anticoagulation pathway may contribute, at least partly, to further promotion of thrombin production induced by AF. Combined with other classical thrombophilic risk factors, the present findings support possible involvements of AF exposure in the high incidence of PTE in early puerperium. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0929-5305 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1573-742X |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
34228247 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s11239-021-02513-4 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
J Thromb Thrombolysis-53-208.pdf (505.6 kB)
