| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-08-12 |
| タイトル |
|
|
タイトル |
Extrastriatal dopamine D2/3 receptor binding, functional connectivity, and autism socio-communicational deficits: a PET and fMRI study |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
Lower extrastriatal D2/3R binding in autism |
| 著者 |
Murayama, Chihiro
Iwabuchi, Toshiki
Kato, Yasuhiko
Yokokura, Masamichi
Harada, Taeko
Goto, Takafumi
Tamayama, Taishi
Kameno, Yosuke
Wakuda, Tomoyasu
Kuwabara, Hitoshi
Senju, Atsushi
Nishizawa, Sadahiko
Ouchi, Yasuomi
Yamasue, Hidenori
|
| 書誌情報 |
Molecular Psychiatry
巻 27,
号 4,
p. 2106-2113,
発行日 2022-04
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利 |
|
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41380-022-01464-3 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The social motivation hypothesis of autism proposes that social communication symptoms in autism spectrum disorder (ASD) stem from atypical social attention and reward networks, where dopamine acts as a crucial mediator. However, despite evidence indicating that individuals with ASD show atypical activation in extrastriatal regions while processing reward and social stimuli, no previous studies have measured extrastriatal dopamine D2/3 receptor (D2/3R) availability in ASD. Here, we investigated extrastriatal D2/3R availability in individuals with ASD and its association with ASD social communication symptoms using positron emission tomography (PET). Moreover, we employed a whole-brain multivariate pattern analysis of resting-state functional magnetic resonance imaging (fMRI) to identify regions where functional connectivity atypically correlates with D2/3R availability depending on ASD diagnosis. Twenty-two psychotropic-free males with ASD and 24 age- and intelligence quotient-matched typically developing males underwent [11C]FLB457 PET, fMRI, and clinical symptom assessment. Participants with ASD showed lower D2/3R availability throughout the D2/3R-rich extrastriatal regions of the dopaminergic pathways. Among these, the posterior region of the thalamus, which primarily comprises the pulvinar, displayed the largest effect size for the lower D2/3R availability, which correlated with a higher score on the Social Affect domain of the Autism Diagnostic Observation Schedule-2 in participants with ASD. Moreover, lower D2/3R availability was correlated with lower functional connectivity of the thalamus-superior temporal sulcus and cerebellum-medial occipital cortex, specifically in individuals with ASD. The current findings provide novel molecular evidence for the social motivation theory of autism and offer a novel therapeutic target. |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1359-4184 |
| EISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1476-5578 |
| PubMed番号 |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
35181754 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1038/s41380-022-01464-3 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Mol. Psychiatry-27-2106.pdf (5.8 MB)
