| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-10-11 |
| タイトル |
|
|
タイトル |
Daptomycin resistant Enterococcus faecalis has a mutation in liaX, which encodes a surface protein that inhibits the LiaFSR systems and cell membrane remodeling |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
daptomycin |
| キーワード |
|
|
主題 |
LiaX |
| キーワード |
|
|
主題 |
Enterococcus faecalis |
| キーワード |
|
|
主題 |
whole-genome sequencing |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Ota, Yusuke
Furuhashi, Kazuki
Hayashi, Wataru
Hirai, Nachi
Ishikawa, Jinko
Nagura, Osanori
Yamanaka, Katsumasa
Katahashi, Kazuto
Aoki, Kotaro
Nagano, Noriyuki
Maekawa, Masato
|
| 書誌情報 |
Journal of Infection and Chemotherapy
巻 27,
号 1,
p. 90-93,
発行日 2021-01
|
| 出版者 |
|
|
出版者 |
Elsevier |
| 出版者 |
|
|
出版者 |
日本感染症学会 = The Japanese Association for Infectious Diseases |
| 権利 |
|
|
権利情報 |
Copyright?2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license?http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利 |
|
|
権利情報 |
"This is the accepted manuscript version. The formal published version is available at ""https://doi.org/10.1016/j.jiac.2020.09.004""." |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The emergence of daptomycin (DAP) resistant Enterococcus species has increased worldwide, but the mechanisms for DAP resistance are not fully understood. We report a case of DAP resistant Enterococcus faecalis, from a clinical sample of a patient with diabetic ulcers, after DAP therapy. Whole-genome sequencing analysis revealed that the isolate had a loss-of-function point mutation within liaX encoding DAP-sensing surface protein, which inhibits the LiaFSR systems and cell membrane remodeling. This is the first case report of a clinical DAP resistant E. faecalis with a mutation in liaX. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1341-321X |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1437-7780 |
| NII書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11057978 |
| PubMed番号 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
32972829 |
| 医中誌論文ID |
|
|
|
識別子タイプ |
ICHUSHI |
|
|
関連識別子 |
2021283408 |
| 出版社DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jiac.2020.09.004 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
JIC-27-90.pdf (1.2 MB)
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