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Detection of highly abundant small molecules in the stratum corneum of healthy young women using desorption electrospray ionization-mass spectrometry imaging
http://hdl.handle.net/10271/00004270
http://hdl.handle.net/10271/00004270ebc80401-9638-4ca6-a76f-e3b260747653
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (1.7 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2023-05-24 | |||||||
| タイトル | ||||||||
| タイトル | Detection of highly abundant small molecules in the stratum corneum of healthy young women using desorption electrospray ionization-mass spectrometry imaging | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | Stratum corneum | |||||||
| キーワード | ||||||||
| 主題 | DESI-MSI | |||||||
| キーワード | ||||||||
| 主題 | molecules | |||||||
| キーワード | ||||||||
| 主題 | skin juvenescence | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 脱離エレクトロスプレーイオン化質量分析イメージングによる健康な若年女性の皮膚角層に特徴的な低分子の検出 | |||||||
| 著者 |
WALIULLAH, A.S.M.
× WALIULLAH, A.S.M.
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| 書誌情報 |
Medical Mass Spectrometry 巻 7, 号 1, p. 26-34, 発行日 2023-05 |
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| 出版者 | ||||||||
| 出版者 | 日本医用マススペクトル学会 | |||||||
| 言語 | ja | |||||||
| 出版者 | ||||||||
| 出版者 | Japanese Society for Biomedical Mass Spectrometry | |||||||
| 言語 | en | |||||||
| 権利 | ||||||||
| 言語 | ja | |||||||
| 権利情報 | 出版者の許諾を得て掲載 | |||||||
| 権利 | ||||||||
| 言語 | en | |||||||
| 権利情報 | Copyright 2023 Japanese Society for Biomedical Mass Spectrometry | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Aging reflects skin appearance drastically, which reduces skin juvenescence. However, the small molecules underlying skin juvenescence have not been well studied. We aimed to explore the molecules potentially responsible for young-looking skin. Eleven healthy women aged 24?59 years were recruited and divided into young and middle-aged groups. Multiple layers of the stratum corneum from the cheek area were taken by tape-stripping, followed by desorption electrospray ionization mass spectrometry imaging (DESI-MSI). Overall, five molecules (m/z 284.33, 340.39, 488.39, 628.37, and 863.65) were highly abundant in young subjects. Among them, m/z 284.33 and 340.39 were dominantly detected in each layer of all young subjects. Interestingly, m/z 488.39 and 628.37 were prominent in young subject 4. All of these molecules were gradually decreased in the successive layers of the stratum corneum in subjects 3 and 4 of the young group. These molecules could be endogenous, co-related with youthful skin, or retained from topical cosmetics. Extensive research is indispensable to characterize them and find the relationship between these molecule’s retention capacity in the stratum corneum with different skin parameters. Our findings provide a novel perspective on young skin that could be advantageous in future cosmetic formulations to improve skin juvenescence. | |||||||
| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2022-09-16 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第917号 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 2432-7441 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 2432-745X | |||||||
| NII書誌ID | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA12788254 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.24508/mms.2023.06.001 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
