| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-04-10 |
| タイトル |
|
|
タイトル |
Long-term prognosis of familial adenomatous polyposis with or without mucosectomy |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
familial adenomatous polyposis |
| キーワード |
|
|
主題 |
total colectomy |
| キーワード |
|
|
主題 |
total proctocolectomy |
| キーワード |
|
|
主題 |
hand-sewn ileal pouch–anal anastomosis |
| キーワード |
|
|
主題 |
stapled ileal pouch–anal anastomosis |
| キーワード |
|
|
主題 |
mucosectomy |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Tatsuta, Kyota
Sakata, Mayu
Morita, Yoshifumi
Kikuchi, Hirotoshi
Hiramatsu, Yoshihiro
Fukazawa, Atsuko
Kurachi, Kiyotaka
Takeuchi, Hiroya
|
| 書誌情報 |
International Journal of Colorectal Disease
巻 37,
号 5,
p. 1133-1140,
発行日 2022-05
|
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利 |
|
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00384-022-04154-2 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: This study primarily aimed to compare the long-term prognosis of patients who underwent total colectomy/proctocolectomy with or without mucosectomy to the dentate line for the diagnosis of familial adenomatous polyposis (FAP).
Methods: Patients who underwent total colectomy/proctocolectomy for FAP between January 1979 and December 2020 and were followed up at Hamamatsu University Hospital were included in this study. Those who underwent total proctocolectomy with hand-sewn ileal pouch–anal anastomosis were defined as the mucosectomy group. Those who underwent total colectomy or total proctocolectomy using the stapled ileal pouch–anal anastomosis approach were defined as the no mucosectomy group.
Results: A total of 61 individuals (37 families) were diagnosed during the surveillance period (median, 191 months). Between the mucosectomy (n=24) and no mucosectomy groups (n=34), metachronous rectal cancer was significantly more common in the no mucosectomy group (21% in no mucosectomy vs. 0% in mucosectomy, P=0.02). Overall survival in the no mucosectomy group was worse than that in the mucosectomy group (84.5% in no mucosectomy vs. 100% in mucosectomy at 120 months, 81.1% vs. 90.0% at 240 months, 50.6% vs. 75.0% at 360 months, P=0.09). Cox regression analysis revealed an independent effect of not performing mucosectomy on overall survival (P=0.03).
Conclusion: Long-term surveillance revealed that colectomy or total proctocolectomy without mucosectomy had a negative impact on the overall survival of patients with FAP. Therefore, we recommend total proctocolectomy with mucosectomy, i.e., hand-sewn ileal pouch–anal anastomosis, for FAP. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0179-1958 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1432-1262 |
| NII書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10689874 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
35460038 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00384-022-04154-2 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
IJCD-37-1133.pdf (1.3 MB)
