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選択的セロトニン再吸収抑止物質(SSRI)のLC/MSならびにLC/MS/MSによる迅速測定
http://hdl.handle.net/10271/1756
http://hdl.handle.net/10271/1756f22225f6-99bd-40b4-b58c-950bb04f14e8
名前 / ファイル | ライセンス | アクション |
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FT-23-162.pdf (128.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-08-27 | |||||
タイトル | ||||||
タイトル | 選択的セロトニン再吸収抑止物質(SSRI)のLC/MSならびにLC/MS/MSによる迅速測定 | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
その他のタイトル | ||||||
その他のタイトル | Rapid and simple determination of selective serotonin reuptake inhibitor (SSRI) in human serum or plasma by LC/MS and LC/MS/MS | |||||
著者 |
服部, 秀樹
× 服部, 秀樹× 伊藤, 健次郎× 岩井, 雅枝× 益田, 健史× 水谷, 洋子× 妹尾, 洋× 有信, 哲哉× 熊澤, 武志× 石井, 晃× 鈴木, 修 |
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書誌情報 |
法中毒 = Japanese journal of forensic toxicology 巻 23, 号 2, p. 162-163, 発行日 2005-07-01 |
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出版者 | ||||||
出版者 | 日本法中毒学会 | |||||
権利 | ||||||
権利情報 | © 日本法中毒学会 | |||||
権利 | ||||||
権利情報 | 本文データは日本法中毒学会の許諾のもと掲載しています。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A sensitive, simple and rapid method using LC/MS and LC/MS/MS assay for selective serotonin reuptake inhibitors (SSRIs), in human serum or plasma was investigated in this study. In this method, three SSRIs, paroxetine, sertraline and fluvoxamine were measured; dextromethorphan was used as internal standard (IS). Serum or plasma samples with or without the compounds and IS, which were mixed with formic acid, were directly subjected to LC/MS. In MS spectra, [M + 1]- ions for paroxetine and fluvoxamine, [M - 31]- ion for sertraline were observed as base peaks. For MS/MS analyses, [M + 1] -ions of the compounds were used as precursor ions for these identification and quantitation. The three compounds could be identified above 100 ng/ml serum, using MS and dependent MS/MS. For three compounds, the calibration curves were linear in the range 5 - 80 ng/ml in the serum and the detection limits were under 5 ng/ml serum and 10 ng/ml plasma, respectively. These results indicate that this presented method can be useful to determine the SSRI in human serum or plasma. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09159606 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |