| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
選択的セロトニン再吸収抑止物質（SSRI）のLC/MSならびにLC/MS/MSによる迅速測定 |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| その他のタイトル |
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その他のタイトル |
Rapid and simple determination of selective serotonin reuptake inhibitor (SSRI) in human serum or plasma by LC/MS and LC/MS/MS |
| 著者 |
服部, 秀樹
伊藤, 健次郎
岩井, 雅枝
益田, 健史
水谷, 洋子
妹尾, 洋
有信, 哲哉
熊澤, 武志
石井, 晃
鈴木, 修
|
| 書誌情報 |
法中毒 = Japanese journal of forensic toxicology
巻 23,
号 2,
p. 162-163,
発行日 2005-07-01
|
| 出版者 |
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出版者 |
日本法中毒学会 |
| 権利 |
|
|
権利情報 |
© 日本法中毒学会 |
| 権利 |
|
|
権利情報 |
本文データは日本法中毒学会の許諾のもと掲載しています。 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
A sensitive, simple and rapid method using LC/MS and LC/MS/MS assay for selective serotonin reuptake inhibitors (SSRIs), in human serum or plasma was investigated in this study. In this method, three SSRIs, paroxetine, sertraline and fluvoxamine were measured; dextromethorphan was used as internal standard (IS). Serum or plasma samples with or without the compounds and IS, which were mixed with formic acid, were directly subjected to LC/MS. In MS spectra, [M + 1]- ions for paroxetine and fluvoxamine, [M - 31]- ion for sertraline were observed as base peaks. For MS/MS analyses, [M + 1] -ions of the compounds were used as precursor ions for these identification and quantitation. The three compounds could be identified above 100 ng/ml serum, using MS and dependent MS/MS. For three compounds, the calibration curves were linear in the range 5 - 80 ng/ml in the serum and the detection limits were under 5 ng/ml serum and 10 ng/ml plasma, respectively. These results indicate that this presented method can be useful to determine the SSRI in human serum or plasma. |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09159606 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FT-23-162.pdf (128.4 kB)
