{"_buckets": {"deposit": "4330d624-f529-4d25-893b-e0a55b288b06"}, "_deposit": {"created_by": 4, "id": "3771", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "3771"}, "status": "published"}, "_oai": {"id": "oai:hama-med.repo.nii.ac.jp:00003771", "sets": ["11"]}, "author_link": [], "item_3_biblio_info_5": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-07-10", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "529", "bibliographicPageStart": "519", "bibliographicVolumeNumber": "323", "bibliographic_titles": [{"bibliographic_title": "Journal of Controlled Release ", "bibliographic_titleLang": "en"}]}]}, "item_3_description_10": {"attribute_name": "注記", "attribute_value_mlt": [{"subitem_description": "<参照>出版社サイト:https://doi.org/10.1016/j.jconrel.2020.04.043 ", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_3_description_9": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Tissue factor (TF), which is well known as a trigger molecule of extrinsic coagulation, is found in not only tumor cells but also in stromal cells in tumor tissues. Thus, TF is a candidate molecule to potentially enable targeting of both tumor cells and stromal cells for anti-cancer drug delivery. Herein, we prepared liposomes conjugated with the Fab’ fragment of anti-TF antibody (TF Ab- Lip) and evaluated the capability for drug delivery to stroma-rich tumors for realizing a whole tumor tissue-targetable strategy. When the targetability of TF Ab-Lip to TF-expressing KLN205 squamous tumor cells and NIH3T3 fibroblast cells were examined, TF Ab-Lip was significantly taken up into both cells compared with non-targeted liposomes. Corresponding to this result, doxorubicin-encapsulated TF Ab-Lip (TF Ab-LipDOX) showed potent cytotoxicity against KLN205 cells. In vivo experiments using KLN205 solid tumor-bearing mice indicated that TF Ab-Lip became highly accumulated and distributed widely in not only the tumor cell region but also in the stromal one in the tumor. Treatment with TF Ab-LipDOX significantly suppressed the growth of KLN205 solid tumors. Furthermore, TF Ab-Lip targetable both mouse and human TF (mhTF Ab-Lip) became distributed throughout stroma-rich human pancreatic BxPC3 tumors and the treatment of the BxPC3 tumor-bearing mice with mhTF Ab-LipDOX showed highest tumor suppressive effect. These data suggest that TF Ab-Lip could achieve effective accumulation for stroma-rich tumor treatment.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_3_publisher_6": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_3_relation_26": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "32360306 ", "subitem_relation_type_select": "PMID"}}]}, "item_3_relation_28": {"attribute_name": "出版社DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.jconrel.2020.04.043", "subitem_relation_type_select": "DOI"}}]}, "item_3_relation_34": {"attribute_name": "出版社版", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.jconrel.2020.04.043", "subitem_relation_type_select": "DOI"}}]}, "item_3_rights_7": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright 2020 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "subitem_rights_language": "en"}, {"subitem_rights": "This is the accepted manuscript version. The formal published version is available at \"https://doi.org/10.1016/j.jconrel.2020.04.043\".", "subitem_rights_language": "en"}]}, "item_3_select_2": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_select_item": "Journal Article", "subitem_select_language": "en"}]}, "item_3_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0168-3659", "subitem_source_identifier_type": "PISSN"}]}, "item_3_source_id_20": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1873-4995", "subitem_source_identifier_type": "EISSN"}]}, "item_3_version_type_32": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shimizu, Kosuke", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takeuchi, Yoshihito", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Otsuka, Kazuma", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mori, Tomoya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Narita, Yudai", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takasugi, Shohei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Magata, Yasuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Matsumura, Yasuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Oku, Naoto", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-10-05"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JCR-323-519.pdf", "filesize": [{"value": "9.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 9700000.0, "url": {"label": "JCR-323-519.pdf", "url": "https://hama-med.repo.nii.ac.jp/record/3771/files/JCR-323-519.pdf"}, "version_id": "2cabaa99-659e-459d-88e9-c307174d2979"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Antibody", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "liposome", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pancreatic tumor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "targeting", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tissue factor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tumor stroma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Development of tissue factor-targeted liposomes for effective drug delivery to stroma-rich tumors", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Development of tissue factor-targeted liposomes for effective drug delivery to stroma-rich tumors", "subitem_title_language": "en"}]}, "item_type_id": "3", "owner": "4", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10271/00003896", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-10-05"}, "publish_date": "2021-10-05", "publish_status": "0", "recid": "3771", "relation": {}, "relation_version_is_last": true, "title": ["Development of tissue factor-targeted liposomes for effective drug delivery to stroma-rich tumors"], "weko_shared_id": -1}
Development of tissue factor-targeted liposomes for effective drug delivery to stroma-rich tumors
http://hdl.handle.net/10271/00003896
http://hdl.handle.net/10271/00003896