| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
ANALYSES OF QUINOLONE ANTIMICROBIALS IN HUMAN PLASMA BY CAPILLARY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY/FAST ATOM BOMBARDMENT MASS SPECTROMETRY |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Quinolone antimicrobials |
| キーワード |
|
|
主題 |
Pyridonecarboxylic acids |
| キーワード |
|
|
主題 |
Mass spectrometry |
| キーワード |
|
|
主題 |
Fast atom bombardment |
| キーワード |
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|
主題 |
Liquid chromatography |
| キーワード |
|
|
主題 |
Capillary HPLC |
| キーワード |
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主題 |
Frit FAB |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
キャピラリーHPLC/FAB-MSによるヒト血漿中キノロン系抗菌剤の分析 |
| 著者 |
Hattori, Hideki
Suzuki, Osamu
Seno, Hiroshi
Ishii, Akira
Yamada, Takamichi
|
| 書誌情報 |
ja : 法中毒 = Japanese journal of forensic toxicology
巻 11,
号 3,
p. 166-175,
発行日 1993-12-20
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| 出版者 |
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|
出版者 |
日本法中毒学会 |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
Copyright 日本法中毒学会 |
| 権利 |
|
|
権利情報 |
本文データは日本法中毒学会の許諾のもと掲載しています。 |
| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Capillary high-performance liquid chromatography (HPLC) was combined with frit fast atom bombardment (FAB)-mass spectrometry (MS) , and a detailed procedure has been established for on-line analysis of ten quinolone antimicrobials in human plasma by the HPLC/FAB-MS. A special column switching device for concentration enabled injection of as large as a 500 μｌ sample; and the capillary column (0.5 mm i. d.) enabled introduction of its entire effluent to the frit interface of FAB-MS. These conditions gave much higher sensitivity than that of the previous HPLC/MS systems. The positive FAB mass spectra of ten quinolone carboxylic acid antimicrobials, measured with the present system, showed peaks at m/z MH, MH+H, MH+32 , MH+62 , MH+G, MH-H2O and MH-CO2 in common for most drugs. The MH+ quasi-molecular ions constituted base peaks for all drugs. Every drug, which had been spiked to human plasma, could be detected as a clean peak on mass chromatograms with sufficient sensitivity, with use of each base peak. The detection limit of this method was 0.1-0.2 μg/ml plasma for each drug, although the present method is semi-quantitative. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
09159606 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FT-11-166.pdf (414.0 kB)
