| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
血中三環系抗うつ剤のヘッドスペース固相ミクロ抽出法 |
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言語 |
ja |
| 言語 |
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|
言語 |
jpn |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| その他のタイトル |
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その他のタイトル |
Extraction of tricyclic antidepressants by headspace solid-phase micro extraction (SPME) in human blood |
| 著者 |
李, 暁鵬
熊澤, 武志
佐藤, 啓造
鈴木, 修
|
| 書誌情報 |
ja : 法中毒
en : Japanese journal of forensic toxicology
巻 14,
号 2,
p. 122-123,
発行日 1996-05-15
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| 出版者 |
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|
出版者 |
日本法中毒学会 |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
Copyright 日本法中毒学会 |
| 権利 |
|
|
権利情報 |
本文データは日本法中毒学会の許諾のもと掲載しています。 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
A simple method for the extraction of four tricyclic antidepressants from human whole blood, using the headspace solid-phase micro extraction (SPME) is presented. The human whole blood samples containing four drugs (amitriptyline, chlorimipramine, imipramine and trimipramine) were heated at 100 °C in a septum-capped vial in the presence of NaOH solution, and a polydimethylsiloxane-coated SPME fiber was exposed to the headspace of the vial to allow adsorption of the drugs before capillary gas chromatography (GC) with flame ionization detection. The headspace SPME-GC gave intense peaks for each drugs; only a few small background noises appeared. Recovery of the four drugs with use of the headspace SPME-GC were 5.8-12.9 %. Reproducibility for headspace SPME-GC data was excellent for whole blood samples. The calibration curves for the drugs showed linearity in the range of 31-1000 ng/0.5 ml for whole blood. The detection limits of each drugs were 16-25 ng/0.5 ml for whole blood. From the viewpoints of simplicity, background noises, detection limit and quantitativeness, the present method can be recommended before analyses by GC in forensic toxicology. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
09159606 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FT-14-122.pdf (109.5 kB)
