| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Simple analysis of naphthalene in human whole blood and urine by headspace capillary gas chromatography with large volume injection |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Naphthalene |
| キーワード |
|
|
主題 |
1-Methylnaphtalene |
| キーワード |
|
|
主題 |
Gas chromatography |
| キーワード |
|
|
主題 |
Headspace sampling |
| キーワード |
|
|
主題 |
Large volume injection |
| キーワード |
|
|
主題 |
Polycyclic aromatic hydrocarbon |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Watanabe, Kanako
Hasegawa, Koutaro
Yamagishi, Itaru
Nozawa, Hideki
Suzuki, Osamu
|
| 書誌情報 |
en : Forensic Toxicology
巻 27,
号 2,
p. 98-102,
発行日 2009-07-01
|
| 出版者 |
|
|
出版者 |
Springer |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
Copyright Japanese Association of Forensic Toxicology and Springer 2009 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Naphthalene is still being sold as a moth repellant; there is a possibility that accidental ingestion of such a product by a small infant causes serious poisoning. In this communication, a very simple method for analysis of naphthalene in human whole blood and urine by headspace gas chromatography (GC) has been presented. It neither needs solid-phase microextraction nor cryogenic trapping devices, but needs only a conventional capillary GC instrument with flame ionization detection. The advantage of the method is that as large as 5 ml of headspace vapor can be injected into a GC instrument in the splitless mode for sensitive detection. After heating a diluted whole blood or urine sample containing naphthalene and 1-methylnaphthalene (internal standard, IS) in a 7.0 ml vial at 80℃ for 30 min, 5 ml of the headspace vapor was drawn with a glass syringe and injected into the gas chromatograph. Before injection, the column was set at 50℃ to trap the analytes, and then the oven temperature was programmed up to 300℃. Sharp peaks were obtained for both analyte and IS, and only a few impurity peaks, which did not interfered with the test peaks, appeared especially for whole blood samples. The detection limits (signal-to-noise ratio ≧ 3) were about 0.05 and 0.01 μg/ml for whole blood and urine, respectively. Precision and linearity were also examined to confirm the reliability. Such a simple headspace GC technique with large volume injection can be probably applied also to other low-volatile compounds in biological matrices, and will be useful in forensic toxicological analysis. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18608965 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
18608973 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s11419-009-0074-1 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Forensic_T-27-98.pdf (128.4 kB)
