| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
generalized osteoarthritis |
| キーワード |
|
|
主題 |
markers |
| キーワード |
|
|
主題 |
osteoarthritis |
| キーワード |
|
|
主題 |
radiographic grading |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Takahashi, Masaaki
Naito, Kenichi
Abe, Masashi
Sawada, Tomokazu
Nagano, Akira
|
| 書誌情報 |
en : Arthritis Research & Therapy
巻 6,
号 3,
p. R208-R212,
発行日 2004-03-12
|
| 出版者 |
|
|
出版者 |
BioMed Central Ltd |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
Copyright BioMed Central Ltd |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The aim of this study was to investigate the relationship between the biochemical markers of arthritis and the radiographic grading of osteoarthritis (OA) in knees. Seventy-one women aged 49-85 years with knee OA were studied. Anterior-posterior knee radiographs and hand radiographs were taken in all patients. The radiographic grading of OA in the knee was performed by using the Kellgren-Lawrence criteria and the joint space width. The 71 patients with knee OA were divided into two groups: 37 patients exhibiting generalized osteoarthritis (GOA) and 34 non-GOA patients, according to the grading of their hand radiograph. C-reactive protein (CRP), urinary pyridinoline, YKL-40, plasma matrix metalloproteinase (MMP)-3, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 were measured as the biochemical markers of arthritis. The radiographic grading with the Kellgren-Lawrence scale revealed a significant relationship to the joint space width (P = 0.003): the joint space width decreased with increasing Kellgren-Lawrence grade. All biochemical markers had negative correlations with the joint space width, but only urinary pyridinoline had a significant correlation (P = 0.039). Pyridinoline (P = 0.034) and TIMP-1 (P = 0.017) also exhibited a significant relationship to the Kellgren-Lawrence grade. In GOA evaluations, the joint space width did not differ between GOA and non-GOA patients. CRP, pyridinoline, YKL-40 and MMP-3 levels were significantly greater in GOA patients than in non-GOA patients. CRP, pyridinoline, YKL-40, MMP-3 and TIMP-1 levels each related to at least one of the radiographic gradings. Furthermore, pyridinoline related to every type of radiographic grading examined in the present study. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14786354 |
| 出版社DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1186/ar1166 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ar-2004_6-208.pdf (154.3 kB)
