| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Expression of tight junction protein claudin-5 in tumor vessels and sinusoidal endothelium in patients with hepatocellular carcinoma. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
hepatocellular carcinoma |
| キーワード |
|
|
主題 |
tight junction |
| キーワード |
|
|
主題 |
claudin |
| キーワード |
|
|
主題 |
sinusoid |
| キーワード |
|
|
主題 |
angiogenesis |
| キーワード |
|
|
主題 |
microvessel density |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sakaguchi, Takanori
Suzuki, Shohachi
Higashi, Hiroyuki
Inaba, Keisuke
Nakamura, Satoshi
Baba, Satoshi
Kato, Tomoyuki
Konno, Hiroyuki
|
| 書誌情報 |
en : Journal of Surgical Research
巻 147,
p. 123-131,
発行日 2008-06-01
|
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
Copyright 2008 Elsevier Inc |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background. A n increase of leaky vasculature is vital for the growth and metastasis of hepatocellular carcinoma (HCC). The paracellular permeability-regulating proteins in tumor vessels and adjacent sinusoids have not been studied in HCC patients. Methods. Expression of an endothelial tight junction protein claudin-5 (CL-5) and a standard endothelial marker CD34 were immunohistochemically examined in resected specimens from 51 HCC cases. The relationship between hepatitic or fibrotic grade and CL-5 expression pattern in sinusoidal endothelial cells (SECs) was evaluated in the tumor-adjacent tissues. Microvessel density (MVD) highlighted by CD34 or CL-5 was examined in tumor tissues. Results. In the normal liver, a ubiquitous CL-5 expression was seen in SECs, the arteries, and portal veins but not in the central veins. Sinusoidal CL-5 expression was down-regulated according to the increase of hepatitic or fibrotic grade. Poor differentiation and vasculobiliary invasion were significantly associated with a lower CL-5-MVD but not CD34-MVD. By multivariate analysis, vasculobiliary invasion and lower CL-5-MVD were independent factors associated with a lower postoperative overall survival rate. Conclusions. Attenuated CL-5 expression in SECs may be related to SEC dysfunction in injured liver. Down-regulated CL-5 expression in tumor vessels may serve as a potential marker for poor prognosis in HCC. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00224804 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
10958673 |
| 出版社DOI |
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|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jss.2007.07.013 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
J_Surg_Res-147-123.pdf (656.1 kB)
