| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Radiotherapy |
| キーワード |
|
|
主題 |
Bone metastasis |
| キーワード |
|
|
主題 |
Pathological fracture |
| キーワード |
|
|
主題 |
Radiological change |
| キーワード |
|
|
主題 |
Bone healing |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
原田, 英幸
Katagiri, Hirohisa
Kamata, Minoru
Yoshioka, Yasuo
Asakura, Hirofumi
Hashimoto, Takayuki
Furutani, Kazuhisa
Takahashi, Mitsuru
Sakahara, Harumi
Nishimura, Tetsuo
|
| 書誌情報 |
en : Journal of Radiation Research
巻 51,
号 2,
p. 131-136,
発行日 2009-11-23
|
| 出版者 |
|
|
出版者 |
THE JAPAN RADIATION RESEARCH SOCIETY |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
Copyright 2010 by THE JAPAN RADIATION RESEARCH SOCIETY |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJ-STAGEから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We evaluated the radiological response and clinical outcome in patients with femoral bone metastases after radiotherapy. 102 consecutive patients with femoral metastases without pathological fracture were treated by surgery or radiotherapy between 2002 and 2005. Twelve of them initially treated with surgery were excluded from this study. The remaining 90 patients with 102 lesions underwent radiation therapy as the initial treatment. Twelve patients who died within 30 days by disease progression and 6 who were lost to follow-up were excluded. The remaining 72 patients with 84 lesions including 43 impending fractures were enrolled in this analysis. Radiological changes were categorized into complete response, partial response, no change, and progressive disease based on plain radiograph findings. Pain relief was reviewed for 77 painful lesions. The median radiation dose was 30 Gy. No re-irradiation was performed. 35 lesions (42%) achieved radiological responses median 3 months after radiotherapy. Pain relief was obtained in 36 of 77 lesions (47%). There was no significant correlation between radiological response and pain relief (P = 0.166). Eleven lesions eventually required surgery and considered as treatment failure. The treatment failure rate in the radiological progressive disease (PD) group (8/19, 42%) was significantly higher than that in the non-PD group (3/65, 5%) (P < 0.001). Among 43 impending fracture lesions, 15 lesions (36%) experienced radiological response and 35 lesions (81%) required no surgical interventions. Our data suggest that radiotherapy can enable metastatic bone healing and avoid surgery in many lesions. However, radiological PD lesions often require surgery after radiotherapy. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
04493060 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13499157 |
| 出版社DOI |
|
|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1269/jrr.09096 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JRadiatRes-51-131.pdf (290.2 kB)
