| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-12-25 |
| タイトル |
|
|
タイトル |
Facile Preparation of Multi-grams of trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, a Precursor of Benzopyrene Diol Epoxide |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
facile preparation |
| キーワード |
|
|
主題 |
multi-grams synthesis |
| キーワード |
|
|
主題 |
BPDE |
| キーワード |
|
|
主題 |
carcinogen |
| キーワード |
|
|
主題 |
thermal instability |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Kurono, Nobuhito
Iwashita, Yuji
Sugimura, Haruhiko
|
| 書誌情報 |
en : Organic Preparations and Procedures Internationa
巻 54,
号 5,
p. 457-464,
発行日 2022
|
| 出版者 |
|
|
出版者 |
Taylor & Francis |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
This is an Accepted Manuscript of an article published by Taylor & Francis in Organic Preparations and Procedures Internationa on 2022, available at: https://doi.org/10.1080/00304948.2022.2081026. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Carcinogenic benzo[a]pyrene diol epoxide (BPDE) is one of the essential materials in tumor pathological research; however, it is expensive and unstable. In addition, its synthetic intermediates are metabolic intermediates of BPDE; thus, there is a need to reduce the handling of these compounds during the synthesis. Accordingly, a precursor of BPDE (i.e., trans-7,8-dihydro-7,8-dihydroxybenzo[a]pyrene) was prepared in a multi-gram scale by modified procedures. Efficient work-ups (e.g., simple extraction and precipitation) were also improved, which resulted in a crude product with high target compound content in each step of the synthesis. |
| 注記 |
|
|
内容記述 |
雑誌掲載タイトル：Facile Multi-gram Preparation of trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, a Precursor of Benzopyrene Diol Epoxide |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0030-4948 |
| EISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1945-5453 |
| NII書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00765353 |
| 出版社DOI |
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|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1080/00304948.2022.2081026 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
OPPI-54-457.pdf (304 KB)
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