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Facile Preparation of Multi-grams of trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, a Precursor of Benzopyrene Diol Epoxide
http://hdl.handle.net/10271/0002000061
http://hdl.handle.net/10271/0002000061c9f301ee-b03d-49f9-bf3d-02ff4f7512e1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
OPPI-54-457.pdf (304 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2023-12-25 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Facile Preparation of Multi-grams of trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, a Precursor of Benzopyrene Diol Epoxide | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 主題 | facile preparation | |||||||||||
| キーワード | ||||||||||||
| 主題 | multi-grams synthesis | |||||||||||
| キーワード | ||||||||||||
| 主題 | BPDE | |||||||||||
| キーワード | ||||||||||||
| 主題 | carcinogen | |||||||||||
| キーワード | ||||||||||||
| 主題 | thermal instability | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
Kurono, Nobuhito
× Kurono, Nobuhito
× Iwashita, Yuji
× Sugimura, Haruhiko
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| 書誌情報 |
en : Organic Preparations and Procedures Internationa 巻 54, 号 5, p. 457-464, 発行日 2022 |
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| 出版者 | ||||||||||||
| 出版者 | Taylor & Francis | |||||||||||
| 言語 | en | |||||||||||
| 権利 | ||||||||||||
| 権利情報 | This is an Accepted Manuscript of an article published by Taylor & Francis in Organic Preparations and Procedures Internationa on 2022, available at: https://doi.org/10.1080/00304948.2022.2081026. | |||||||||||
| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Carcinogenic benzo[a]pyrene diol epoxide (BPDE) is one of the essential materials in tumor pathological research; however, it is expensive and unstable. In addition, its synthetic intermediates are metabolic intermediates of BPDE; thus, there is a need to reduce the handling of these compounds during the synthesis. Accordingly, a precursor of BPDE (i.e., trans-7,8-dihydro-7,8-dihydroxybenzo[a]pyrene) was prepared in a multi-gram scale by modified procedures. Efficient work-ups (e.g., simple extraction and precipitation) were also improved, which resulted in a crude product with high target compound content in each step of the synthesis. | |||||||||||
| 注記 | ||||||||||||
| 内容記述 | 雑誌掲載タイトル：Facile Multi-gram Preparation of trans-7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene, a Precursor of Benzopyrene Diol Epoxide | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 0030-4948 | |||||||||||
| EISSN | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 1945-5453 | |||||||||||
| NII書誌ID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00765353 | |||||||||||
| 出版社DOI | ||||||||||||
| 関連タイプ | isVersionOf | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.1080/00304948.2022.2081026 | |||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | AM | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||
