| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-02-21 |
| タイトル |
|
|
タイトル |
Treatment with prednisolone and tacrolimus versus prednisolone and cyclosporin A for polymyositis/dermatomyositis-associated interstitial lung disease: a randomized, open-label trial |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
dermatomyositis |
| キーワード |
|
|
主題 |
polymyositis |
| キーワード |
|
|
主題 |
interstitial lung disease |
| キーワード |
|
|
主題 |
tacrolimus |
| キーワード |
|
|
主題 |
cyclosporin A |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| その他のタイトル |
|
|
その他のタイトル |
PSL and TAC treatment in PM/DM-ILD |
| 著者 |
Fujisawa, Tomoyuki
Hozumi, Hironao
Kamiya, Yosuke
Kaida, Yusuke
Akamatsu, Taisuke
Kusagaya, Hideki
Satake, Yasuomi
Mori, Kazutaka
Mikamo, Masashi
Matsuda, Hiroyuki
Yokomura, Koshi
Koshimizu, Naoki
Toyoshima, Mikio
Imokawa, Shiro
Yasui, Hideki
Suzuki, Yuzo
Karayama, Masato
Furuhashi, Kazuki
Enomoto, Noriyuki
Nakamura, Yutaro
Inui, Naoki
Suda, Takafumi
|
| 書誌情報 |
en : Respirology
巻 26,
号 4,
p. 370-377,
発行日 2021-03-17
|
| 出版者 |
|
|
出版者 |
John Wiley and Sons |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
This is the peer reviewed version of the following article: "Prednisolone and tacrolimus versus prednisolone and cyclosporin A to treat polymyositis/dermatomyositis-associated ILD: A randomized, open-label trial", Volime 26, Issue 4, pp.370-377, 2021, which has been published in final form at https://doi.org/10.1111/resp.13978. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background and Objective
The efficacy of combination therapy with corticosteroids and calcineurin inhibitors (CNIs), tacrolimus (TAC) and cyclosporin A (CsA), for polymyositis/dermatomyositis-associated interstitial lung diseases (PM/DM-ILD) has been described retrospectively. However, it remains unknown which CNIs treatment regimens, TAC or CsA regimens, are more effective as initial treatments for patients with PM/DM-ILD.
Methods
We conducted a prospective multicenter, open-label, randomized, 52-week phase 2 trial. Patients with PM/DM-ILD were randomly allocated to receive prednisolone (PSL) plus TAC (TAC group) or PSL plus CsA (CsA group). The primary endpoint was progression-free survival (PFS) rate in the intention-to-treat population at 52 weeks. The secondary endpoints were overall survival (OS) rate at 52 weeks, changes in pulmonary function tests from baseline to 52 weeks, and adverse events (AEs).
Results
Fifty-eight patients were randomly assigned to the TAC group (n=30) and the CsA group (n=28). The PFS rates at 52 weeks were 87% in the TAC group and 71% in the CsA group (p=0.16). The OS rates at 52 weeks were 97% in the TAC group and 93% in the CsA group (p=0.50). The %FVC at 52 weeks in the per protocol populations significantly increased in both groups. None of the patients discontinued the treatment due to AEs.
Conclusions
PSL plus TAC treatment was more likely to be associated with a higher short-term PFS rate compared with PSL plus CsA treatment. Further studies must be conducted to evaluate the longterm efficacy and safety of such treatment. |
| 注記 |
|
|
内容記述 |
雑誌掲載タイトル：Prednisolone and tacrolimus versus prednisolone and cyclosporin A to treat polymyositis/dermatomyositis-associated ILD: A randomized, open-label trial |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1323-7799 |
| EISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1440-1843 |
| NII書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11097269 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
33179395 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/resp.13978 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Respirology-26-370.pdf (572 KB)
