| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-05-17 |
| タイトル |
|
|
タイトル |
Influence of daily vs. alternate-day dosing of vonoprazan on intragastric pH, serum gastrin, and the antiplatelet function of clopidogrel |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
vonoprazan |
| キーワード |
|
|
主題 |
alternate-day dosing |
| キーワード |
|
|
主題 |
clopidogrel |
| キーワード |
|
|
主題 |
ADP-induced platelet aggregation |
| キーワード |
|
|
主題 |
gastrin |
| キーワード |
|
|
主題 |
pH4 holding time ratio |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| その他のタイトル |
|
|
その他のタイトル |
Influence of alternate-day dosing of vonoprazan |
| 著者 |
Higuchi, Tomohiro
Yamade, Mihoko
Takahashi, Satoru
Tamura, Satoshi
Tani, Shinya
Kagami, Takuma
Uotani, Takahiro
Hamaya, Yasushi
Iwaizumi, Moriya
Osawa, Satoshi
Sugimoto, Ken
Furuta, Takahisa
|
| 書誌情報 |
en : European Journal of Clinical Pharmacology
巻 78,
号 6,
p. 955-963,
発行日 2022-06
|
| 出版者 |
|
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出版者 |
Springer Nature |
|
言語 |
en |
| 権利 |
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|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00228-022-03313-2 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Vonoprazan, a potassium-competitive acid blocker, inhibits gastric acid secretion and attenuates the antiplatelet function of clopidogrel more potently than esomeprazole. We investigated whether alternate-day dosing of vonoprazan might avoid this interaction with clopidogrel while providing sufficient gastric acid inhibition.
Methods: Following 24 h of pH monitoring (control regimen), 12 healthy volunteers received three regimens (clopidogrel-only regimen: clopidogrel 75mg daily (q.d.); vonoprazan alternate-day regimen: vonoprazan 10mg every other day (q.o.d.) + clopidogrel 75mg q.d.; vonoprazan daily regimen: vonoprazan 10mg q.d. + clopidogrel 75mg q.d. for 14 days in a randomized open-label crossover manner. Intragastric pH monitoring was performed for 24 hours on day 13 in the clopidogrel-only regimen and vonoprazan q.d. regimens and for 48 hours on days 13 and 14 in the vonoprazan q.o.d. regimen. Serum gastrin and inhibition of platelet aggregation (IPA) were measured before the commencement of pH monitoring in each regimen.
Results: Twelve volunteers completed the study. Equivalent median IPA values in the q.o.d. and q.d. regimens were measured (21.8% and 25%, respectively) and were significantly lower than that of the clopidogrel-only regimen (40.8%). Median pH4 holding time ratio on the vonoprazan q.o.d. regimen (49.7%) was superior to that of the clopidogrel-only regimen (18.4%), but was significantly inferior to that of the vonoprazan q.d. regimen (77.0%) (p<0.01).
Conclusion: Alternate-day administration of vonoprazan could not prevent the interaction between vonoprazan and clopidogrel and acid inhibition was inferior to vonoprazan daily administration, and appears to be of questionable clinical utility. |
| 注記 |
|
|
内容記述 |
雑誌掲載タイトル：Influence of daily versus alternate-day dosing of vonoprazan on intragastric pH, serum gastrin, and the antiplatelet function of clopidogrel |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0031-6970 |
| EISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1432-1041 |
| NII書誌ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00639585 |
| PubMed番号 |
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関連タイプ |
isVersionOf |
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識別子タイプ |
PMID |
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関連識別子 |
35445847 |
| 出版社DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1007/s00228-022-03313-2 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
EJCP-78-955.pdf (664 KB)
