| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-02-26 |
| タイトル |
|
|
タイトル |
Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Cardiovascular surgical procedures |
| キーワード |
|
|
主題 |
Cognitive dysfunction |
| キーワード |
|
|
主題 |
Post-intensive care unit delirium |
| キーワード |
|
|
主題 |
Mental status and dementia tests |
| キーワード |
|
|
主題 |
Remimazolam sedation |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Aoki, Yoshitaka
Kurita, Tadayoshi
Nakajima, Mikio
Imai, Ryo
Suzuki, Yuji
Makino, Hiroshi
Kinoshita, Hiroyuki
Doi, Matsuyuki
Nakajima, Yoshiki
|
| 書誌情報 |
en : Journal of Anesthesia
巻 37,
号 1,
p. 13-22,
発行日 2023-02
|
| 出版者 |
|
|
出版者 |
Springer Nature |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
日本麻酔科学会 = Japanese Society of Anesthesiologists |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00540-022-03119-7 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Purpose: Postoperative delirium is one of the most common complications after cardiovascular surgery in older adults. Benzodiazepines are a reported risk factor for delirium; however, there are no studies investigating remimazolam, a novel anesthetic agent. Therefore, we prospectively investigated the effect of remimazolam on postoperative delirium.
Methods: We included elective cardiovascular surgery patients aged ≥ 65 years at Hamamatsu University Hospital between August 2020 and February 2022. Patients who received general anesthesia with remimazolam were compared with those who received other anesthetics (control group). The primary outcome was delirium within 5 days after surgery. Secondary outcomes were delirium during intensive care unit stay and hospitalization, total duration of delirium, subsyndromal delirium, and differences in the Mini-Mental State Examination scores from preoperative to postoperative days 2 and 5. To adjust for differences in the groups’ baseline covariates, we used stabilized inverse probability weighting as the primary analysis and propensity score matching as the sensitivity analysis.
Results: We enrolled 200 patients; 78 in the remimazolam group and 122 in the control group. After stabilized inverse probability weighting, 30.3% of the remimazolam group patients and 26.6% of the control group patients developed delirium within 5 days (risk difference, 3.8%; 95% confidence interval, −11.5% to 19.1%; p=0.63). The secondary outcomes did not differ significantly between the groups, and the sensitivity analysis results were similar to those for the primary analysis.
Conclusion: Remimazolam was not significantly associated with postoperative delirium compared with other anesthetic agents. |
| ISSN |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0913-8668 |
| EISSN |
|
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1438-8359 |
| NII書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10852931 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
36220948 |
| 医中誌論文ID |
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|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
ICHUSHI |
|
|
関連識別子 |
2024046927 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1007/s00540-022-03119-7 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
JA-37-13.pdf (991 KB)
