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  1. 学術雑誌論文
  2. 各雑誌掲載論文
  1. 学術雑誌論文
  2. 浜松医科大学優秀論文賞

A predictive model for acute exacerbation of idiopathic interstitial pneumonias

http://hdl.handle.net/10271/0002000364
http://hdl.handle.net/10271/0002000364
8c96967b-126c-4a22-8de2-abebd548340f
名前 / ファイル ライセンス アクション
最優秀_ERJ-61-2201634.pdf ERJ-61-2201634.pdf (890 KB)
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Item type 学術雑誌論文 / Journal Article(1)
公開日 2025-04-15
タイトル
タイトル A predictive model for acute exacerbation of idiopathic interstitial pneumonias
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 Karayama, Masato

× Karayama, Masato

en Karayama, Masato
Hamamatsu University School of Medicine

ja ISNI 浜松医科大学 0000000089376696

ja-Kana ハママツイカダイガク

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Aoshima, Yoichiro

× Aoshima, Yoichiro

en Aoshima, Yoichiro

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Suzuki, Takahito

× Suzuki, Takahito

en Suzuki, Takahito

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Mori, Kazutaka

× Mori, Kazutaka

en Mori, Kazutaka
Shizuoka City Shimizu Hospital

ja ISNI 静岡市立清水病院 0000000417723416

ja-Kana シズオカシリツシミズビョウイン

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Yoshizawa, Nobuko

× Yoshizawa, Nobuko

en Yoshizawa, Nobuko

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Ichikawa, Shintaro

× Ichikawa, Shintaro

en Ichikawa, Shintaro

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Kato, Shinpei

× Kato, Shinpei

en Kato, Shinpei
Seirei Mikatahara General Hospital

ja ISNI 聖隷三方原病院 0000000417648727

ja-Kana セイレイミカタハラビョウイン

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Yokomura, Koshi

× Yokomura, Koshi

en Yokomura, Koshi

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Kono, Masato

× Kono, Masato

en Kono, Masato
Seirei Hamamatsu General Hospital

ja ISNI 聖隷浜松病院 0000000403778408

ja-Kana セイレイハママツビョウイン

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Hashimoto, Dai

× Hashimoto, Dai

en Hashimoto, Dai

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Inoue, Yusuke

× Inoue, Yusuke

en Inoue, Yusuke

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Yasui, Hideki

× Yasui, Hideki

en Yasui, Hideki

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Hozumi, Hironao

× Hozumi, Hironao

en Hozumi, Hironao

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Suzuki, Yuzo

× Suzuki, Yuzo

en Suzuki, Yuzo

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Furuhashi, Kazuki

× Furuhashi, Kazuki

en Furuhashi, Kazuki

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Fujisawa, Tomoyuki

× Fujisawa, Tomoyuki

en Fujisawa, Tomoyuki

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Enomoto, Noriyuki

× Enomoto, Noriyuki

en Enomoto, Noriyuki

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Goshima, Satoshi

× Goshima, Satoshi

en Goshima, Satoshi

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Inui, Naoki

× Inui, Naoki

en Inui, Naoki

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Suda, Takafumi

× Suda, Takafumi

en Suda, Takafumi

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書誌情報 en : European Respiratory Journal

巻 61, 号 5, p. 2201634, 発行日 2023-05-05
出版者
出版者 European Respiratory Society
言語 en
権利
権利情報 (C) The authors 2023. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
抄録
内容記述タイプ Abstract
内容記述 Background
Acute exacerbation of idiopathic interstitial pneumonias (AE-IIPs) induces permanent pulmonary dysfunction and is potentially lethal. The unpredictable occurrence of AE-IIPs remains an important clinical issue in the management of IIPs.
Methods
In this multicentre, retrospective, observational study, a predictive score for AE-IIPs was designed using clinical factors based on multivariate Fine–Gray analysis in patients with IIPs.
Results
Based on multivariate Fine–Gray analysis in an exploratory cohort of 487 patients with IIPs, the predictive score for AE-IIPs was determined as follows: 1 point each was added for honeycombing on high-resolution computed tomography (H), age >75 years (A) and lactate dehydrogenase level >222 U·L−1 (L); the total score ranged from 0 to 3 (HAL score). The HAL score discriminated the risk of AE-IIPs with a C-index of 0.62 (95% CI 0.56–0.67); this discrimination was verified in a validation cohort of 402 patients with IIPs with a C-index of 0.67 (95% CI 0.60–0.73). In a combined cohort, the estimated
cumulative risks for AE-IIPs at 1, 2, 3, 5 and 10 years were 1.9%, 3.5%, 5.1%, 7.7% and 12.9%, respectively, in the total score 0 group; 4.7%, 8.3%, 12.0%, 17.7% and 28.4%, respectively, in the total score 1 group; and 8.0%, 14.2%, 19.7%, 28.7% and 43.0%, respectively, in the total score ⩾2 group. Subgroup analysis revealed that the HAL score was applicable to patients with and without idiopathic pulmonary fibrosis.
Conclusions
The HAL score discriminated the risk of AE-IIPs and could aid in the management of IIPs.
注記
内容記述 令和6年度 浜松医科大学優秀論文賞:最優秀論文賞
受賞者:柄山 正人
ISSN
収録物識別子タイプ PISSN
収録物識別子 0903-1936
EISSN
収録物識別子タイプ EISSN
収録物識別子 1399-3003
NII書誌ID
収録物識別子タイプ NCID
収録物識別子 AA10688995
PubMed番号
関連タイプ isIdenticalTo
識別子タイプ PMID
関連識別子 36822633
出版社DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 https://doi.org/10.1183/13993003.01634-2022
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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