| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-04-15 |
| タイトル |
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|
タイトル |
A predictive model for acute exacerbation of idiopathic interstitial pneumonias |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Karayama, Masato
Aoshima, Yoichiro
Suzuki, Takahito
Mori, Kazutaka
Yoshizawa, Nobuko
Ichikawa, Shintaro
Kato, Shinpei
Yokomura, Koshi
Kono, Masato
Hashimoto, Dai
Inoue, Yusuke
Yasui, Hideki
Hozumi, Hironao
Suzuki, Yuzo
Furuhashi, Kazuki
Fujisawa, Tomoyuki
Enomoto, Noriyuki
Goshima, Satoshi
Inui, Naoki
Suda, Takafumi
|
| 書誌情報 |
en : European Respiratory Journal
巻 61,
号 5,
p. 2201634,
発行日 2023-05-05
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| 出版者 |
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出版者 |
European Respiratory Society |
|
言語 |
en |
| 権利 |
|
|
権利情報 |
(C) The authors 2023. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background
Acute exacerbation of idiopathic interstitial pneumonias (AE-IIPs) induces permanent pulmonary dysfunction and is potentially lethal. The unpredictable occurrence of AE-IIPs remains an important clinical issue in the management of IIPs.
Methods
In this multicentre, retrospective, observational study, a predictive score for AE-IIPs was designed using clinical factors based on multivariate Fine–Gray analysis in patients with IIPs.
Results
Based on multivariate Fine–Gray analysis in an exploratory cohort of 487 patients with IIPs, the predictive score for AE-IIPs was determined as follows: 1 point each was added for honeycombing on high-resolution computed tomography (H), age >75 years (A) and lactate dehydrogenase level >222 U·L−1 (L); the total score ranged from 0 to 3 (HAL score). The HAL score discriminated the risk of AE-IIPs with a C-index of 0.62 (95% CI 0.56–0.67); this discrimination was verified in a validation cohort of 402 patients with IIPs with a C-index of 0.67 (95% CI 0.60–0.73). In a combined cohort, the estimated
cumulative risks for AE-IIPs at 1, 2, 3, 5 and 10 years were 1.9%, 3.5%, 5.1%, 7.7% and 12.9%, respectively, in the total score 0 group; 4.7%, 8.3%, 12.0%, 17.7% and 28.4%, respectively, in the total score 1 group; and 8.0%, 14.2%, 19.7%, 28.7% and 43.0%, respectively, in the total score ⩾2 group. Subgroup analysis revealed that the HAL score was applicable to patients with and without idiopathic pulmonary fibrosis.
Conclusions
The HAL score discriminated the risk of AE-IIPs and could aid in the management of IIPs. |
| 注記 |
|
|
内容記述 |
令和6年度 浜松医科大学優秀論文賞：最優秀論文賞
受賞者：柄山 正人 |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0903-1936 |
| EISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1399-3003 |
| NII書誌ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA10688995 |
| PubMed番号 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
PMID |
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関連識別子 |
36822633 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.1183/13993003.01634-2022 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
ERJ-61-2201634.pdf (890 KB)
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