| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
Intracranial self-stimulation increases differentially in vivo hydroxylation of tyrosine but similarly in vivo hydroxylation of tryptophan in rat medial prefrontal cortex, nucleus accumbens and striatum |
| 言語 |
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|
言語 |
eng |
| キーワード |
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|
主題 |
3,4-Dihydroxyphenylalanine |
| キーワード |
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|
主題 |
5-Hydroxytryptophan |
| キーワード |
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主題 |
Intracranial self-stimulation |
| キーワード |
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|
主題 |
Medial prefrontal cortex |
| キーワード |
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|
主題 |
Nucleus accumbens |
| キーワード |
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主題 |
Striatum |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Nakamura, Masato
Furukawa, Hiromu
Furuno, Nario
|
| 書誌情報 |
Brain Research
巻 864,
号 1,
p. 124-129,
発行日 2000-03-02
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| 出版者 |
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出版者 |
Elsevier Science B.V |
| 権利 |
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|
権利情報 |
© 2000 Elsevier Science B.V. |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
We have examined using microdialysis the effect of intracranial self-stimulation (ICSS) on the in vivo hydroxylation rate of tyrosine and tryptophan in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC) and striatum (STR). A decarboxylase inhibitor NSD-1015 was included in the perfusate, which enabled the simultaneous measurement of 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) as an index of the in vivo hydroxylation level of tyrosine and tryptophan. When rats were exposed to 1 h of ICSS at the medial forebrain bundle (MFB), their extracellular levels of DOPA significantly increased in the mPFC, NAC and STR, but with a different magnitude and time course. The same stimulation produced a delayed increase in extracellular 5-HTP, compared to DOPA, in these brain regions. The profile of 5-HTP response demonstrated no apparent difference among the regions. These findings indicate that ICSS of the MFB can increase differentially the in vivo hydroxylation of tyrosine but similarly the in vivo hydroxylation of tryptophan in the mPFC, NAC and STR. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00068993 |
| 出版社DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/S0006-8993(00)02166-1 |
| 著者版フラグ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
BrainRes864_1-124.pdf (701.4 kB)
