| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Characterization of murine T-cell epitopes on mycobacterial DNA-binding protein 1 (MDP1) using DNA vaccination |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
DNA immunization |
| キーワード |
|
|
主題 |
T-cell epitope |
| キーワード |
|
|
主題 |
Mycobacterium tuberculosis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Suzuki, Daisuke
Nagata, Toshi
Matsumoto, Sohkichi
Matsumoto, Makoto
Tsujimura, Kunio
Koide, Yukio
|
| 書誌情報 |
Vaccine
巻 28,
号 8,
p. 2020-2025,
発行日 2010-02-23
|
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利 |
|
|
権利情報 |
Copyright 2009 Elsevier Ltd |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Mycobacterial DNA-binding protein 1 (MDP1) is a major protein antigen in mycobacteria and induces protective immunity against Mycobacterium tuberculosis infection in mice. In this study we determined murine T-cell epitopes on MDP1 with MDP1 DNA immunization in mice. We analyzed interferon-γ production from the MDP1 DNA-immune splenocytes in response to 20-mer overlapping peptides covering MDP1 protein. We identified several CD4+ T-cell epitopes in three inbred mouse strains and one CD8+ T-cell epitope in C57BL/6 mice. These T-cell epitopes would be feasible for analysis of the role of MDP1-specific T-cells in protective immunity and for future vaccine design against M. tuberculosis infection. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0264410X |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.vaccine.2009.10.062 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Vaccine28_6-2020.pdf (249.3 kB)
