| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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タイトル |
R０LE OF α1-ADRENERGIC RECEPTORS AND THE EFFECT OF BUNAZOSIN ON THE HISTOPATHOLOGY OF CARDIOMYOPATHIC SYRIAN HAMSTERS OF STRAIN BIO 14.6 |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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主題 |
α_1 -adrenergic receptor |
| キーワード |
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主題 |
Cardiomyopathic syrian hamster |
| キーワード |
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主題 |
Bunazosin |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ikegaya, Takayoshi
Nishiyama, Terumasa
Kobayashi, Akira
Yamazaki, Noboru
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| 書誌情報 |
Japanese circulation journal
巻 52,
号 2,
p. 181-187,
発行日 1988-02-20
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| 出版者 |
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出版者 |
日本循環器学会 |
| 権利 |
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|
権利情報 |
Copyright 日本循環器学会 |
| 権利 |
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権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
In order to clarify the pathological involvement of the sympathetic nervous system in the development of cardiomyopathy, a receptor-binding study was carried out on cardiomyopathic Syrian hamsters of strain BIO 14.6 (BIO) at 21 days (prenecrotic stage); 35-42 days (onset of cardiomyopathy); and 70-84 days of life (early cardiac hypertrophy). The newly developed α_1-blocker (bunazosin hydrochloride) was initially administered at doses of 100 μg/kg or 10 mg/kg BIO hamsters at 21 days of life and continued for 70 days. At the onset of cardiomyopathy and early cardiac hypertrophy, there was an increase in the number of α_1-receptors in the BIO hamsters compared to controls, but there were no significant changes at the prenecrotic stage. On histopathological examination, 10 mg/kg bunazosin had a singnificant beneficial effect on cardiomyopathy [area of necrosis 1.38% in untreated vs 0.33% in treated animals; area of calcification 2.70% (untreated) vs 0.60% (treated); area of all myocardial injuries 6.97% (untreated) vs 3.19% (treated)]. However, 100 μg/kg bunazosin had no effect. It was concluded that the increase in the number of α_1-receptors may not be involved in the pathogenesis of cardiomyopathy but that α_1-receptors could be implicated in the later progression of the condition. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00471828 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1253/jcj.52.181 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
CircJ52_2-181.pdf (968.0 kB)
