| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
Metabolite alterations in the hippocampus of high-functioning adult subjects with autism |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Aggression |
| キーワード |
|
|
主題 |
autism |
| キーワード |
|
|
主題 |
hippocampus |
| キーワード |
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|
主題 |
magnetic resonance spectroscopy |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Suzuki, Katsuaki
Nishimura, Katsuhiko
Sugihara, Genichi
Nakamura, Kazuhiko
Tsuchiya, Kenji J.
Matsumoto, Kaori
Takebayashi, Kiyokazu
Isoda, Haruo
Sakahara, Harumi
Sugiyama, Toshiro
Tsujii, Masatsugu
Takei, Nori
Mori, Norio
|
| 書誌情報 |
Int J Neuropsychopharmacol
巻 13,
p. 529-534,
発行日 2009-11-09
|
| 出版者 |
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出版者 |
CINP |
| 権利 |
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|
権利情報 |
Copyright CINP |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The aim of the present study was to investigate metabolite alterations in the hippocampal formation as they relate to aggression in high-functioning adults with autism. We measured concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr+PCr) in the hippocampal formation by proton magnetic resonance spectroscopy in 12 non-medicated male subjects with autism and 12 age- and sex-matched controls. Aggression was scored in the autistic subjects using the Buss-Perry Aggression Questionnaire. The concentrations of Cho and Cr+PCr in the hippocampal formation in autistic subjects were significantly higher than the corresponding values in control subjects, and a significant positive correlation was observed between the concentrations of these metabolites in the hippocampal formation and scores on the Buss-Perry Aggression Questionnaire in autistic subjects. Results suggest that high-functioning adult subjects with autism have abnormal metabolite concentrations in the hippocampal formation, which may in part account for their aggression. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
14611457 |
| 出版社DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1017/S1461145709990952 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
IntJNP9-1.pdf (115.1 kB)
