| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Effects of L-carnitine on Action Potential of Canine Papillary Muscle Impaired by Long Chain Acyl Carnitine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Palmitoyl carnitine |
| キーワード |
|
|
主題 |
Free fatty acid |
| キーワード |
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|
主題 |
Arrhythmogenesis |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hayashi, Hideharu
Suzuki, Yoshikazu
Masumura, Yoshinori
Kamikawa, Tadashi
Kobayashi, Akira
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Heart Journal
巻 23,
号 4,
p. 623-630,
発行日 1981-08-25
|
| 出版者 |
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|
出版者 |
International Heart Journal Association |
| 権利 |
|
|
権利情報 |
by International Heart Journal Association |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
It has been reported that long chain acyl carnitine accumulates in ischemic myocardium, and L-carnitine prevents ventricular arrhythmias as well as the accumulation of long chain acyl carnitine in ischemic and free fatty acid supplemented hearts. The purpose of this study was to observe the electrophysiological effects of long chain acyl carnitine, and to evaluate the protective effect of L-carnitine on the transmembrane action potential impaired by long chain acyl carnitine. Using standard microelectrode techniques, transmembrane action potentials were recorded from isolated canine papillary muscle. Palmitoyl carnitine (0.3mM and 0.6mM) decreased the resting membrane potential, action potential amplitude and maximum upstroke velocity of phase 0, and shortened action potential duration and effective refractory period in a concentration-dependent manner. Application of L-carnitine (25mM) prevented the effect of palmitoyl carnitine (0.3mM) on the transmembrane action potential. These results suggest that long chain acyl carnitine plays an important role in arrhythmogenesis, and that the effect is prevented by L-carnitine. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00214868 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1348673X |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1536/ihj.23.623 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JHeartJ-23-623.pdf (350.5 kB)
