| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Effects of L-Carnitine on Arrhythmias during Hemodialysis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Holter electrocardiography |
| キーワード |
|
|
主題 |
High plasma free fatty acids |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Suzuki, Yoshikazu
Narita, Masayasu
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Heart Journal
巻 23,
号 3,
p. 349-359,
発行日 1981-06-06
|
| 出版者 |
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|
出版者 |
International Heart Journal Association |
| 権利 |
|
|
権利情報 |
by International Heart Journal Association |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The therapeutic effect of L-carnitine on arrhythmias during hemodialysis was evaluated in 17 patients with chronic renal disease undergoing intermittent hemodialysis. In 11 of 17 patients (65%), ventricular or supraventricular premature beats appeared at 20 to 30min after the start of hemodialysis and continued throughout the dialysis. Plasma carnitine was at a lower level in the predialysis period (24.8±7.9n mole/ml) as compared with the normal human levels (46.1±8.6n mole/ml), and decreased markedly by the end of dialysis (8.2±5.9n mole/ml). Plasma free fatty acids rapidly increased immediately after the start of dialysis, reached the maximum levels after 20min (from 0.23±0.09 to 1.31±0.64mEq/L) and maintained higher levels even at the end of dialysis (0.76± 0.29mEq/L). Administration of L-carnitine (2Gm orally), 2 hours before the start of dialysis, maintained plasma carnitine within normal levels throughout the dialysis and suppressed the increase in plasma free fatty acids. Both the incidence and the severity of premature beats during hemodialysis were significantly reduced by oral administration of L-carnitine (2Gm daily) for 4 to 8 weeks. These results suggest that L-carnitine is useful for the treatment of hemodialysis arrhythmias, presumably by restoring impaired oxidation of free fatty acids. |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00214868 |
| EISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1348673X |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1536/ihj.23.349 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JHeartJ-23-349.pdf (444.6 kB)
