| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Changes of Cyclic AMP Concentration to Isoproterenol after Abrupt Cessation of Propranolol in Rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Propranolol withdrawal syndrome |
| キーワード |
|
|
主題 |
Beta adrenergic receptor |
| キーワード |
|
|
主題 |
Hyperadrenergic state |
| キーワード |
|
|
主題 |
Cyclic AMP |
| キーワード |
|
|
主題 |
Isoproterenol |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Kobayashi, Akira
Ogawa, Kohichi
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Heart Journal
巻 21,
号 3,
p. 399-407,
発行日 1979-07-13
|
| 出版者 |
|
|
出版者 |
International Heart Journal Association |
| 権利 |
|
|
権利情報 |
by International Heart Journal Association |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Because the mechanism of adverse reactions to abrupt cessation of propranolol in patients with coronary heart disease was an enigma, we studied the effect of cessation of propranolol on beta-adrenergic receptor reactivity to catecholamine stimulation. The cyclic AMP concentrations in plasma and left ventricular muscle after the administration of isoproterenol (5mg/Kg) were measured in rats before, during, 2 days after, and 4 days after of the administration of propranolol (5mg/Kg). Two days after withdrawal from propranolol, the cyclic AMP concentrations in plasma and left ventricular muscle were significantly increased (p<0.005, p<0.01). Four days after withdrawal from propranolol, the cyclic AMP concentration in plasma was significantly increased (p<0.001). On the other hand, that of left ventricular muscle showed a tendency to have higher value, although, this was statistically not significant. From these results, this study supports that there is a hypersensitivity to adrenergic stimulation after abrupt cessation of long-term propranolol treatment. The explanation of propranolol withdrawal phenomenon most likely lies in the nature of beta adrenergic receptors that become activated during long-term blockade. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00214868 |
| EISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1348673X |
| 出版社DOI |
|
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1536/ihj.21.399 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JHeartJ-21-399.pdf (531.9 kB)
