| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
Effects of Thymoxamine in Ouabain-Induced Arrhythmias in Dogs |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
alpha blocker |
| キーワード |
|
|
主題 |
thymoxamine |
| キーワード |
|
|
主題 |
phentolamine |
| キーワード |
|
|
主題 |
ouabain-induced arrhythmias |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Oguro, Katsunori
Hashimoto, Hisakuni
Nakashima, Mitsuyoshi
|
| 書誌情報 |
The Tohoku Journal of Experimental Medicine
巻 137,
号 4,
p. 361-368,
発行日 1981-03-06
|
| 出版者 |
|
|
出版者 |
東北ジャーナル刊行会 |
| 権利 |
|
|
権利情報 |
東北ジャーナル刊行会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The effect of thymoxamine, a pure alpha-adrenoceptor blocking agent, on ouabain-induced arrhythmias was investigated in dogs to clarify whether thymoxamine has an arrhythmogenic or an anti-arrhythmic action. Thymoxamine, 1mg/kg i.v., inhibited the manifestation of ventricular arrhythmias (VA) and the pressor effect produced by ouabain infusion (1μg/kg/min i.v.) as 5mg/ kg i.v. of phentolamine did. Low doses of these drugs did not affect the VA. Simultaneous infusion of phenylephrine (5μg/kg/min i.v.) with ouabain enhanced the manifestation of VA accompanying pressor effects, which were inhibited by thymoxamine (1mg/kg) in a parallel manner. Infusion of isoprenaline (0.2μg/ kg/min i.v.) with ouabain enhanced the manifestation of VA, but the enhancement was to a lesser extent than with phenylephrine. Thymoxamine, 1mg/kg, did not affect the VA. The infusion of CaCl2 (20mg/kg/min i.v.) with ouabain enhanced the manifestation of VA, which was not inhibited by thymoxamine. These results show the possibility that the protective effect of thymoxamine on the manifestation of VA may be mainly associated with inhibitions of pressor effects mediated through vascular alpha-adrenoceptors. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00408727 |
| EISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13493329 |
| 出版社DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1620/tjem.137.361 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
Tohoku Journal-137-361.pdf (734.6 kB)
