| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
Ca2+ TRANSIENTS AND CELL SHORTENING IN DIABETIC RAT VENTRICULAR MYOCYTES |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Indo-1 |
| キーワード |
|
|
主題 |
〔Ca2+〕i |
| キーワード |
|
|
主題 |
Cell contraction |
| キーワード |
|
|
主題 |
Isoproterenol |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Noda, Naohisa
Hayashi, Hideharu
Satoh, Hiroshi
Terada, hajime
Hirano, Masahiko
Kobayashi, Akira
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Circulation Journal
巻 57,
号 5,
p. 449-457,
発行日 1992-05-22
|
| 出版者 |
|
|
出版者 |
日本循環器学会 |
| 権利 |
|
|
権利情報 |
Copyright日本循環器学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
To investigate the role of abnormal Ca2+ metabolism in the diminished contractile function of diabetic myocardium, we measured the Ca2+ transients and cell contraction of diabetic rat myocytes. Isolated diabetic (8 weeks after 40 mg/kg streptozotocin, i.v.) and normal myocytes were loaded with acetoxymethyl ester of indo-1 (indo-1/AM). Ca2+ transients and cell circumferential shortening were measured simultaneously, using high temporal resolution video image analysis. The diastolic base and systolic peak of Ca2+ transients were significantly lower in diabetic myocytes than in normal myocytes (peak ratios: 0.49±0.02 vs 0.56±0.01, p<0.05; base ratios: 0.43±0.01 vs 0.48±0.01, p<0.01, Mea±SE). The cell circumferential shortening of diabetic myocytes was also significantly lower than that of normal myocytes (2.9±0.3% vs 5.2±0.9%, p<0.05). Although isoproterenol (10-8 and 10-7 M) increased the peak of Ca2+ transients in both diabetic and normal myocytes, the peak value of Ca2+ transients in the diabetic group was significantly lower than that in the normal group. The decreased Ca2+ transients may be responsible for the decreased contractile function in diabetic myocardium |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00471828 |
| EISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13474839 |
| 出版社DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1253/jcj.57.449 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JCircJ-157-449.pdf (1.0 MB)
