| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
EFFECTS OF PROPRANOLOL AND DILTIAZEM ON THE RATE OF HIGH-ENERGY PHOSPHATE METABOLISM IN REPERFUSED RAT HEARTS |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
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|
主題 |
Saturation transfer |
| キーワード |
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|
主題 |
Reperfused heart |
| キーワード |
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|
主題 |
Propranolol |
| キーワード |
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|
主題 |
Diltiazem |
| キーワード |
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|
主題 |
31P-NMR |
| キーワード |
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|
主題 |
High-energy phosphate |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Okayama, Yoshimi
Kobayashi, Akira
Fujise, Yutaka
Yamazaki, Noboru
|
| 書誌情報 |
Japanese Circulation Journal
巻 57,
号 6,
p. 521-532,
発行日 1992-04-30
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| 出版者 |
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出版者 |
日本循環器学会 |
| 権利 |
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|
権利情報 |
Copyright日本循環器学会 |
| 権利 |
|
|
権利情報 |
本文データは学協会の許諾に基づきJournal Archiveから複製したものである |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The relationships between pressure rate product (PRP) and flux (PCr→ATP) or flux (Pi→ATP) were studied in isolated perfused rat hearts by the saturation transfer method using 31P-NMR. The effects of propranolol and diltiazem on phosphate metabolism were also studied. After a 40 min preischemic period, the hearts were subjected to a 15 min period of ischemia, followed by 60 min of reperfusion. Propranolol (0.4-1.2μM) or diltiazem (3.0-6.0μM) was infused for 30 min before ischemia and reinfused after reperfusion for 60 min. The flux (PCr→ATP)/PRP ratio at reperfusion did not differ from that at preischemia. This value was also not affected by propranolol or diltiazem treatment. However, the flux (Pi→ATP)/PRP ratio at reperfusion was significantly less than that at preischemia. Moreover, this value was significantly improved by propranolol or diltiazem treatment. This study demonstrates that 1) flux (PCr→ATP) has a good correlation with cardiac performance, 2) stunned myocardium needs less ATP turnover for survival of its depressed contractile activity, and 3) flux (Pi→ATP) can limit recovery of postischemic performance. Protective effects of propranolol and diltiazem are exerted on the flux (Pi-ATP), i.e. ATP derived from glycolytic flux, in the reperfused heart. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
00471828 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13474839 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1253/jcj.57.521 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
JCircJ-57-521.pdf (1.2 MB)
