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A radioiodinated quinazolin derivative can predict radiosensitivity in non-small cell lung cancer
http://hdl.handle.net/10271/2767
http://hdl.handle.net/10271/276732306f14-4291-4e51-9725-f4f2de2df622
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (374 KB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2015-10-06 | |||||||
| タイトル | ||||||||
| タイトル | A radioiodinated quinazolin derivative can predict radiosensitivity in non-small cell lung cancer | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | [125I]PYK | |||||||
| キーワード | ||||||||
| 主題 | irradiation | |||||||
| キーワード | ||||||||
| 主題 | gefitinib | |||||||
| キーワード | ||||||||
| 主題 | EGFR | |||||||
| キーワード | ||||||||
| 主題 | NSCLC | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 放射性ヨウ素標識キナゾリン誘導体は非小細胞肺癌において放射線感受性を予測しうる | |||||||
| 著者 |
Zhu, Huijun
× Zhu, Huijun
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| 書誌情報 |
発行日 2013-09-20 |
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Objective The aim of this study was to determine whether the uptake of radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3′-iodophenoxy) quinazoline ([125I]PYK) can predict the response to radiotherapy of NSCLC cells in vitro. Methods Four NSCLC cell lines PC9, HCC827, A549 and H1975 were used. The cells were irradiated with doses ranging from 2 Gy to 8 Gy and/or exposed to 1 μM gefitinib. The effects of radiation and gefitinib were assessed by CCK-8 assay. The uptake of [125I]PYK was determined by incubating cells with the tracer. Cell cycle and EGFR expression were assessed by flow cytometry. Results The uptake of [125I]PYK in PC9 and HCC827 cells was higher than in A549 and H1975 cells. PC9 cells and HCC827 cells were more radiosensitive than A549 and H1975 cells. Gefitinib pretreatment reduced S phase fraction and enhanced radiation effect in PC9 and HCC827 cells. Conclusion The uptake of [125I]PYK related to the effect of radiation in NSCLC cells. The results suggested that radioiodinated PYK might be useful in predicting the response of NSCLC in patients to radiotherapy. |
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| 言語 | en | |||||||
| 注記 | ||||||||
| 内容記述 | 雑誌掲載タイトル：Relationship between uptake of a radioiodinated quinazoline derivative and radiosensitivity in non-small cell lung cancer 雑誌名：American Journal of Nuclear Medicine and Molecular Imaging 巻号：Volume 4, No.4 : p293-384, 2014 |
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| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2013-09-20 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第659号 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
