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Lack of functional MHC class Ⅰ leads to altered dopamine system and ADHD-like behavior in mice
http://hdl.handle.net/10271/2770
http://hdl.handle.net/10271/27708ac0af16-ad68-4936-b118-5f580e38acc0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (2.8 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2021-10-01 | |||||||
| タイトル | ||||||||
| タイトル | Lack of functional MHC class Ⅰ leads to altered dopamine system and ADHD-like behavior in mice | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | マウスにおけるMHCクラスⅠの機能阻害はドーパミン系を変化させADHD様行動を惹起する | |||||||
| 著者 |
孟, 紅蕊
× 孟, 紅蕊
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| 書誌情報 |
発行日 2013-09-20 |
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Midbrain dopamine systems play a crucial role in the regulation of many behavioral processes and their abnormalities underlie the development of several psychiatric diseases such as attention deficit hyperactivity disorder (ADHD), autism and schizophrenia. These systems express the major histocompatibility complex class I (MHCI), a neuro-immune molecule recently identified to be present in the neurons and glial cells of the brain. The MHCI molecules regulate neural connectivity and plasticity in the developing as well as adult brain. Here we report that mice in which functional MHCI has been lacked exhibit hyperactivity, motor impulsiveness and attention deficits that are three major symptoms of ADHD. They also show alterations in the gene expression of dopamine synthetic enzyme, transporter and receptor subtypes in the cell body and terminal areas of the midbrain dopamine systems. Moreover, their behavioral phenotypes are improved, although not completely reversed, by methylphenidate, an ADHD medicine. These results indicate important behavioral functions for the MHCI molecules within the brain and suggest novel therapeutic targets for ADHD and other psychiatric disorders related to the malfunctions of midbrain dopamine systems. | |||||||
| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2013-09-20 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第663号 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
