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Impact of gender in renal cell carcinoma: the relationship of FABP7 and BRN2 expression with overall survival
http://hdl.handle.net/10271/2786
http://hdl.handle.net/10271/2786ec69bc5c-d4e6-429d-83a0-c358083562e0
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
論文本文 (947.0 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2015-01-09 | |||||||
| タイトル | ||||||||
| タイトル | Impact of gender in renal cell carcinoma: the relationship of FABP7 and BRN2 expression with overall survival | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | BRN2 | |||||||
| キーワード | ||||||||
| 主題 | FABP7 | |||||||
| キーワード | ||||||||
| 主題 | gender | |||||||
| キーワード | ||||||||
| 主題 | overall survival | |||||||
| キーワード | ||||||||
| 主題 | renal cell carcinoma | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 腎癌における性別の影響: 全生存期間に及ぼすFABP7 とBRN2 発現の関係 | |||||||
| 著者 |
Tan, Cheng
× Tan, Cheng
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| 書誌情報 |
en : Clinical Medicine Insights: Oncology 発行日 2014 |
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| 出版者 | ||||||||
| 出版者 | SAGE Publications | |||||||
| 言語 | en | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Objective: To investigate the relationship between gender differences in fatty acid-binding protein7 (FABP7) and BRN2 (POU class 3 homeobox 2) expression in renal cell carcinoma (RCC) and the prognosis of patients with RCC. Materials and Methods: immunohistochemical (IHC) staining as well as reverse transcription-polymerase chain reaction (RT-PCR) was performed in renal tissues from 103 patients (83 men, mean age=63.6 years old; 20 women, mean age=63.1 years old) underwent radical nephrectomy from January 1, 2001 through December 31, 2010. The probability of overall patient survival was estimated using the Kaplan-Meier method. Results: FABP7 mRNA expression was more frequent in men (P=0.07) while BRN2 protein expression was significantly more frequent in women (P=0.029). In particular, FABP7 was expressed in 100% of G1 renal cell carcinoma both in mRNA and protein levels. In women, FABP7 (-) and BRN2 (+) groups had a worse prognosis both in mRNA level (P=0.038) and protein level (P=0.058). BRN2 was expressed 100% of papillary RCC both in mRNA and protein levels. Conclusions: Our results demonstrated that gender was a key factor in FABP7 and BRN2 expression in RCC, and the combination with FABP7 and BRN2 stratified by gender could be a new potential prognostic factor in patients with RCC. |
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| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2014-03-17 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第682号 | |||||||
| EISSN | ||||||||
| 収録物識別子タイプ | EISSN | |||||||
| 収録物識別子 | 1179-5549 | |||||||
| PubMed番号 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 24653654 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.4137/CMO.S13684 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
