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Loud noise exposure during activity and neurogenesis in the living rat brain: A preliminary study
http://hdl.handle.net/10271/2904
http://hdl.handle.net/10271/2904d865ae75-cb47-407a-bb6c-0f2bd4f9870b
| 名前 / ファイル | ライセンス | アクション |
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論文本文 (318.9 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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| 公開日 | 2015-11-20 | |||||||
| タイトル | ||||||||
| タイトル | Loud noise exposure during activity and neurogenesis in the living rat brain: A preliminary study | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| キーワード | ||||||||
| 主題 | Neurogenesis | |||||||
| キーワード | ||||||||
| 主題 | Noise | |||||||
| キーワード | ||||||||
| 主題 | Rat | |||||||
| キーワード | ||||||||
| 主題 | [18F]FLT | |||||||
| キーワード | ||||||||
| 主題 | Positron emission tomography | |||||||
| キーワード | ||||||||
| 主題 | subventricular zone | |||||||
| キーワード | ||||||||
| 主題 | hippocampal subgranular zone | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| その他のタイトル | ||||||||
| その他のタイトル | 活動中の騒音曝露と生体ラット脳内での神経新生 : 予備的検討 | |||||||
| 著者 |
Shimizu, Yoshiyuki
× Shimizu, Yoshiyuki
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| 書誌情報 |
en : Journal of Neurology & Neurophysiology 発行日 2014 |
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| 出版者 | ||||||||
| 出版者 | OMICS International | |||||||
| 言語 | en | |||||||
| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Objective: The effects of loud noise (80 dB) on neurogenesis in the subventricular zone (SVZ) and the hippocampal subgranular zone (SGZ) was investigated in vivo in the rat brain using positron emission tomography (PET) with 3’-deoxy-3’-[18F]fluoro-L-thymidine ([18F]FLT), a marker for thymidine kinase I (TK-1) related to cell proliferation and for neurogenesis in SVZ and SGZ. Methods: Five young Sprague-Dawley rats were exposed to loud noise from two speakers set in front of their cages during the night for 4 nights, and 5 control rats were exposed to normal quiet conditions. PET was performed 4 days after the exposure. Results: The accumulation of [18F]FLT in SVZ was significantly lower in the rats with noise exposure than in the control rats. The level of [18F]FLT uptake was lower in the SVZ than in the SGZ. Conclusion: Our results indicate that loud noise exposure during the awake period may be related to the decrease in proliferative capacity of neural stem cells especially in the SVZ of the living rat brain. This finding may indicate that persistent loud noise during daily life is harmful to brain development in humans. |
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| 言語 | en | |||||||
| 学位名 | ||||||||
| 学位名 | 博士（医学） | |||||||
| 学位の区分 | ||||||||
| 内容記述 | doctoral | |||||||
| 学位の分野 | ||||||||
| 内容記述 | 医学系研究科 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 13802 | |||||||
| 学位授与機関名 | 浜松医科大学 | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2015-03-16 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第696号 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | PISSN | |||||||
| 収録物識別子 | 2155-9562 | |||||||
| 出版社DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.4172/2155-9562 | |||||||
| 著者版フラグ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
