{"_buckets": {"deposit": "c1b57cd0-15d6-47d2-9ca0-fd42a7964bd6"}, "_deposit": {"created_by": 4, "id": "3641", "owners": [4], "pid": {"revision_id": 0, "type": "depid", "value": "3641"}, "status": "published"}, "_oai": {"id": "oai:hama-med.repo.nii.ac.jp:00003641", "sets": ["11"]}, "author_link": [], "item_3_biblio_info_5": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-05", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "54", "bibliographicPageStart": "47", "bibliographicVolumeNumber": "143", "bibliographic_titles": [{"bibliographic_title": "Lung Cancer"}]}]}, "item_3_description_30": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_3_description_9": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objectives: Conventional evaluation of anti-tumor activity on the basis of tumor size is inadequate for immune checkpoint inhibitors (ICIs). We therefore aimed to assess the usefulness of intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) for evaluation of the therapeutic efficacy of ICIs.\nMaterials and Methods: A chest IVIM-MRI was performed before and 2, 4, and 8 weeks after administration of ICIs in patients with advanced non-small-cell lung cancer. Apparent diffusion coefficient (ADC), skewness of ADC (ADCskew), kurtosis of ADC (ADCkurt), true diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were evaluated at each evaluation point and changes from the baseline (Δ).\nResults: Twenty patients were enrolled in this study. An increased ADC 8 weeks and decreased ADCkurt and ΔADCkurt 4 weeks after ICIs was associated with objective responses and longer progression-free survival (PFS). A decreased ΔADCskew at 4 weeks was associated with objective responses, disease control, and longer PFS and overall survival. There was no correlation between the efficacy of ICIs and D, D* and f. All of three patients who had pseudoprogression had decreased ΔADCskew at 4 weeks and two of them had decreased ΔADCkurt at 4 weeks. Inversely, all five patients who had progressive disease (PD) did not have increased ΔADCskew at 4 weeks and only one of them had decreased ΔADCkurt at 4 weeks.\nConclusions: Changes in histograms of ADC may be useful for predicting long-term efficacy and distinguishing between pseudoprogression and actual PD after ICIs.", "subitem_description_type": "Abstract"}]}, "item_3_publisher_6": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_3_relation_26": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "32203770", "subitem_relation_type_select": "PMID"}}]}, "item_3_relation_28": {"attribute_name": "出版社DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.lungcan.2020.03.013", "subitem_relation_type_select": "DOI"}}]}, "item_3_rights_7": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/."}]}, "item_3_select_2": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_select_item": "Journal Article", "subitem_select_language": "en"}]}, "item_3_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0169-5002", "subitem_source_identifier_type": "ISSN"}]}, "item_3_source_id_20": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1872-8332", "subitem_source_identifier_type": "ISSN"}]}, "item_3_version_type_32": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Karayama, Masato"}]}, {"creatorNames": [{"creatorName": "Yoshizawa, Nobuko"}]}, {"creatorNames": [{"creatorName": "Sugiyama, Masataka"}]}, {"creatorNames": [{"creatorName": "Mori, Kazutaka"}]}, {"creatorNames": [{"creatorName": "Yasui, Hideki "}]}, {"creatorNames": [{"creatorName": "Hozumi, Hironao"}]}, {"creatorNames": [{"creatorName": "Suzuki, Yuzo"}]}, {"creatorNames": [{"creatorName": "Furuhashi, Kazuki"}]}, {"creatorNames": [{"creatorName": "Fujisawa, Tomoyuki"}]}, {"creatorNames": [{"creatorName": "Enomoto, Noriyuki"}]}, {"creatorNames": [{"creatorName": "Nakamura, Yutaro"}]}, {"creatorNames": [{"creatorName": "Inui, Naoki"}]}, {"creatorNames": [{"creatorName": "Goshima, Satoshi"}]}, {"creatorNames": [{"creatorName": "Suda, Takafumi"}]}, {"creatorNames": [{"creatorName": "Takehara, Yasuo"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-06-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Lung Cancer-143-47.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "Lung Cancer-143-47.pdf ", "url": "https://hama-med.repo.nii.ac.jp/record/3641/files/Lung Cancer-143-47.pdf"}, "version_id": "90fc9753-109f-4b69-890e-a1d394bcb27e"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "IVIM-MRI", "subitem_subject_scheme": "Other"}, {"subitem_subject": "immune therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anti-programmed death-1 therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anti-PD-1 therapy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pseudoprogression", "subitem_subject_scheme": "Other"}, {"subitem_subject": "atypical radiologic response", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer", "subitem_title_language": "en"}]}, "item_type_id": "3", "owner": "4", "path": ["11"], "permalink_uri": "http://hdl.handle.net/10271/00003773", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-06-01"}, "publish_date": "2021-06-01", "publish_status": "0", "recid": "3641", "relation": {}, "relation_version_is_last": true, "title": ["Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer"], "weko_shared_id": -1}
Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer
http://hdl.handle.net/10271/00003773
http://hdl.handle.net/10271/00003773