| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2021-10-01 |
| タイトル |
|
|
タイトル |
HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Histone deacetylase 3 |
| キーワード |
|
|
主題 |
XPC |
| キーワード |
|
|
主題 |
Histone H3K14 |
| キーワード |
|
|
主題 |
Ultraviolet |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
HDAC3 is involved in NER |
| 著者 |
Nishimoto, Koji
Niida, Hiroyuki
Uchida, Chiharu
Ohhata, Tatsuya
Kitagawa, Kyoko
Motegi, Akira
Suda, Takafumi
Kitagawa, Masatoshi
|
| 書誌情報 |
Molecular Cancer Research
巻 18,
号 9,
p. 1367-1378,
発行日 2020-09
|
| 出版者 |
|
|
出版者 |
American Association for Cancer Research |
| 権利 |
|
|
権利情報 |
"""This manuscript has been accepted for publication in """"Molecular Cancer Research"""", which is published by the American Association for Cancer Research.""" |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Recent studies have demonstrated that lysine acetylation of histones is crucial for nucleotide excision repair (NER) by relaxing the chromatin structure, which facilitates the recruitment of repair factors. However, few studies have focused on the contribution of histone deacetylases (HDACs) to NER. Here, we found that histone H3 Lys14 (H3K14) was deacetylated by HDAC3 after UV irradiation. Depletion of HDAC3 caused defects in cyclobutene pyrimidine dimer excision and sensitized cells to UV irradiation. HDAC3-depleted cells had impaired unscheduled DNA synthesis, but not recovery of RNA synthesis, which indicates that HDAC3 was required for global genome NER. Moreover, accumulation of XPC at the local UV-irradiated area was attenuated in HDAC3-depleted cells. In addition to the delay of XPC accumulation at DNA damage sites, ubiquitylation of XPC was inhibited in HDAC3-depleted cells. These results suggest that the deacetylation of histone H3K14 by HDAC3 after UV irradiation contributes to XPC recruitment to DNA lesions to promote global genome NER. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1541-7786 |
| EISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1557-3125 |
| PubMed番号 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
32527949 |
| 出版社DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1158/1541-7786.MCR-20-0214 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
Mol. Cancer Res.-18-1367.pdf (11.5 MB)
