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Associations between plasma hydroxylated metabolite of itraconazole and serum creatinine in patients with a hematopoietic or immune-related disorder
http://hdl.handle.net/10271/00003902
http://hdl.handle.net/10271/0000390229a5e6c6-628c-4103-9708-3d91505f0415
| 名前 / ファイル | ライセンス | アクション |
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EJCP-77-369.pdf (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2021-10-08 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Associations between plasma hydroxylated metabolite of itraconazole and serum creatinine in patients with a hematopoietic or immune-related disorder | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | itraconazole | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | metabolite | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | pharmacokinetics | |||||||||||||||
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| 主題 | creatinine | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | renal function | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | cystatin C | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Imoto, Yumi
× Imoto, Yumi
× Naito, Takafumi
× Miyadera, Yukari
× Ono, Takaaki
× Kawakami, Junichi
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| 書誌情報 |
European Journal of Clinical Pharmacology 巻 77, 号 3, p. 369-379, 発行日 2021-03 |
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| 出版者 | Springer Nature | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | "This is a post-peer-review, pre-copyedit version of an article published in ""European Journal of Clinical Pharmacology"". The final authenticated version is available online at: https://doi.org/10.1007/s00228-020-03010-y." | |||||||||||||||
| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Purpose: Serum markers of renal function have not been characterized in patients treated with itraconazole (ITZ). This study aimed to evaluate the associations between plasma ITZ and its hydroxylated metabolite (OH-ITZ) concentrations and serum markers of renal function in hematopoietic or immune-related disorder patients. Methods: This study enrolled 40 hematopoietic or immune-related disorder patients receiving oral ITZ solution. Plasma concentrations of ITZ and OH-ITZ at 12 hours after dosing were determined at steady state. Their relationships with serum levels of creatinine and cystatin C, and their estimated glomerular filtration rate (eGFR) were evaluated. Results: The free plasma concentration of ITZ had no correlation with serum creatinine and serum creatinine-based estimated glomerular filtration rate (eGFR-cre). The free plasma concentration of OH-ITZ was positively and negatively correlated with serum creatinine and eGFR-cre, respectively. The free plasma concentrations of ITZ and OH-ITZ had no association with serum cystatin C and serum cystatin C-based eGFR. Serum creatinine was higher by 16% after than before starting ITZ treatment, while eGFR-cre was lower by 9.3%. The serum creatinine ratio after/before ITZ treatment was positively correlated with the free plasma concentration of OH-ITZ. The patients co-treated with trimethoprim-sulfamethoxazole had higher serum creatinine. Concomitant glucocorticoid administration did not significantly alter serum cystatin C. Conclusions: Hematopoietic or immune-related disorder patients treated with oral ITZ had a higher level of serum creatinine. Although serum creatinine potentially increases in conjunction with the free plasma concentration of OH-ITZ, concomitant ITZ administration has a slight impact on the eGFR-cre level in clinical settings. |
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| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 0031-6970 | |||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 1432-1041 | |||||||||||||||
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| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | 33033881 | |||||||||||||||
| 出版社DOI | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1007/s00228-020-03010-y | |||||||||||||||
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| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
